VDAC2 (porin-2) expression pattern and localization in the bovine testis

被引：49
作者：
Hinsch, KD [1 ]
Asmarinah [1 ]
Hinsch, E [1 ]
Konrad, L [1 ]
机构：
[1] Univ Giessen, Dept Dermatol & Androl, D-35392 Giessen, Germany
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2001年 / 1518卷 / 03期
关键词：
voltage anion dependent channel 1; voltage anion dependent channel 2; gene expression; spermatocyte; spermatozoon;
D O I：
10.1016/S0167-4781(01)00199-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, sequencing of voltage-dependent anion channel 2 (VDAC2, porin-2) cDNA from bovine testis is reported. High identity to the murine, rabbit, and human subtypes at both the nucleotide and amino acid levels is demonstrated. mRNA analysis revealed expression of VDAC2 in bovine testis, whereas high levels of VDAC2 proteins were found in late spermatocytes, spermatids, and spermatozoa. In contrast, VDAC1 (porin-1) is exclusively localized in Sertoli cells. The possible role of testicular VDAC2 in providing energy metabolites and in germ cell apoptosis is discussed. (C) 2001 Elsevier Science B.V. All rights reserved.
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页码：329 / 333
页数：5
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