[1,2] Boc migration during pyroglutamate alkylations

被引：19

作者：

Dieltiens, N ^{[1
]}

Stevens, CV ^{[1
]}

Masschelein, KGR ^{[1
]}

Rammeloo, T ^{[1
]}

机构：

[1] Univ Ghent, Dept Organ Chem, Res Grp SynBioC, Fac Biosci Engn, B-9000 Ghent, Belgium

来源：

TETRAHEDRON | 2005年 / 61卷 / 28期

关键词：

Boc migration; pyroglutamate; alkylation; carbamates;

D O I：

10.1016/j.tet.2005.05.003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of N-Boc protected pyroglutamates with strong bases lead to a Boc migration front the N-atom to the C2 position when no or poor electrophiles are being used. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6749 / 6756

页数：8

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