The NLRP3 Inflammasome Detects Encephalomyocarditis Virus and Vesicular Stomatitis Virus Infection

被引:111
作者
Rajan, Jayant V. [1 ,2 ]
Rodriguez, David [1 ]
Miao, Edward A. [1 ]
Aderem, Alan [1 ]
机构
[1] Inst Syst Biol, Seattle, WA 98104 USA
[2] Univ Washington, Med Ctr, Dept Med, Seattle, WA 98195 USA
关键词
DOUBLE-STRANDED-RNA; INFLUENZA-VIRUS; ATPASE ACTIVITY; DNA VIRUSES; RIG-I; RECOGNITION; INTERLEUKIN-1; ACTIVATION; RECEPTORS; RESPONSES;
D O I
10.1128/JVI.01687-10
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Inflammasomes are cytosolic protein complexes that regulate caspase-1 activation and the secretion of interleukin-1 beta (IL-1 beta) and IL-18. Several different inflammasome complexes have been identified, but the NLRP3 inflammasome is particularly notable because of its central role in diseases of inflammation. Recent work has demonstrated an essential role for the NLRP3 inflammasome in host defense against influenza virus. We show here that two other RNA viruses, encephalomyocarditis virus (EMCV) and vesicular stomatitis virus (VSV), activate the NLRP3 inflammasome in dendritic cells and macrophages through a mechanism requiring viral replication. Inflammasome activation in response to both viruses does not require MDA5 or RIG-I signaling. Despite the ability of the NLRP3 inflammasome to detect EMCV and VSV, wild-type and caspase-1-deficient mice were equally susceptible to infection with both viruses. These findings indicate that the NLRP3 inflammasome may be a common pathway for RNA virus detection, but its precise role in the host response may be variable.
引用
收藏
页码:4167 / 4172
页数:6
相关论文
共 50 条
  • [21] The NLRP3 Inflammasome and Diabetic Cardiomyopathy
    Singh, Lalit P.
    CARDIOVASCULAR DRUGS AND THERAPY, 2014, 28 (01) : 5 - 6
  • [22] Metabolic Regulation of the NLRP3 Inflammasome
    Ye, Qizhen
    Chen, Sheng
    Wang, Di
    INFECTIOUS MICROBES & DISEASES, 2021, 3 (04): : 183 - 186
  • [23] Mechanism of NLRP3 inflammasome activation
    Sutterwala, Fayyaz S.
    Haasken, Stefanie
    Cassel, Suzanne L.
    YEAR IN IMMUNOLOGY: MYELOID CELLS AND INFLAMMATION, 2014, 1319 : 82 - 95
  • [24] Hyperactivation of the NLRP3 inflammasome protects mice against influenza A virus infection via IL-1β mediated neutrophil recruitment
    Niu, Junling
    Wu, Shuxian
    Chen, Mingkuan
    Xu, Ke
    Guo, Qiuhong
    Lu, Ailing
    Zhao, Liping
    Sun, Bing
    Meng, Guangxun
    CYTOKINE, 2019, 120 : 115 - 124
  • [25] Role of the NLRP3 inflammasome in cancer
    Moossavi, Maryam
    Parsamanesh, Negin
    Bahrami, Afsane
    Atkin, Stephen L.
    Sahebkar, Amirhossein
    MOLECULAR CANCER, 2018, 17
  • [26] HSPA13 modulates type I interferon antiviral pathway and NLRP3 inflammasome to restrict dengue virus infection in macrophages
    Wang, Qiaohua
    Yang, Jingwen
    Li, Xingyu
    Wang, Wei
    Wu, Yongjian
    Li, Zhijian
    Huang, Xi
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 124
  • [27] NLRP3 inflammasome in endothelial dysfunction
    Bai, Baochen
    Yang, Yanyan
    Wang, Qi
    Li, Min
    Tian, Chao
    Liu, Yan
    Aung, Lynn Htet Htet
    Li, Pei-feng
    Yu, Tao
    Chu, Xian-ming
    CELL DEATH & DISEASE, 2020, 11 (09)
  • [28] Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition
    de Carvalho, Renan V. H.
    Lima-Junior, Djalma S.
    da Silva, Marcus Vinicius G.
    Dilucca, Marisa
    Rodrigues, Tamara S.
    Horta, Catarina V.
    Silva, Alexandre L. N.
    da Silva, Patrick F.
    Frantz, Fabiani G.
    Lorenzon, Lucas B.
    Souza, Marcos Michel
    Almeida, Fausto
    Cantanhede, Lilian M.
    Ferreira, Ricardo de Godoi M.
    Cruz, Angela K.
    Zamboni, Dario S.
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [29] Chalcone: A potential scaffold for NLRP3 inflammasome inhibitors
    Thapa, Pritam
    Upadhyay, Sunil P.
    Singh, Vikas
    Boinpelly, Varun C.
    Zhou, Jianping
    Johnson, David K.
    Gurung, Prajwal
    Lee, Eung Seok
    Sharma, Ram
    Sharma, Mukut
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS, 2023, 7
  • [30] Activation of the NLRP3 Inflammasome by Group B Streptococci
    Costa, Alessandro
    Gupta, Rahul
    Signorino, Giacomo
    Malara, Antonio
    Cardile, Francesco
    Biondo, Carmelo
    Midiri, Angelina
    Galbo, Roberta
    Trieu-Cuot, Patrick
    Papasergi, Salvatore
    Teti, Giuseppe
    Henneke, Philipp
    Mancuso, Giuseppe
    Golenbock, Douglas T.
    Beninati, Concetta
    JOURNAL OF IMMUNOLOGY, 2012, 188 (04) : 1953 - 1960