Effects of Weight Loss on FGF-21 in Human Subjects: An Exploratory Study

被引：9
作者：
Headland, Michelle L. [1 ,2 ,3 ]
Clifton, Peter M. [1 ,2 ,3 ]
Keogh, Jennifer B. [1 ,2 ,3 ]
机构：
[1] Univ South Australia, Sch Pharm & Med Sci, Frome Rd, Adelaide, SA 5000, Australia
[2] Univ South Australia, ARENA, Frome Rd, Adelaide, SA 5000, Australia
[3] Univ South Australia, Sansom Inst Hlth Res, Frome Rd, Adelaide, SA 5000, Australia
来源：
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2019年 / 16卷 / 23期
关键词：
intermittent energy restriction; fibroblast growth factor-21; weight loss; FIBROBLAST GROWTH FACTOR-21; Y GASTRIC BYPASS; PPAR-ALPHA; SERUM CONCENTRATIONS; HEPATIC GLUCONEOGENESIS; FASTING RESPONSE; FGF21; REGULATOR; METABOLISM; OBESITY;
D O I：
10.3390/ijerph16234877
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Fibroblast growth factor-21 (FGF-21), is a protein involved in cell growth and differentiation, development, wound repair and metabolism. Research looking at the impact of weight loss on FGF-21 levels is limited. The objective of this exploratory study was to determine changes in serum FGF-21 levels following weight loss induced by either continuous energy restriction or intermittent energy restriction. A sub cohort of participants who completed a 12-month dietary intervention trial following continuous energy restriction, or a week-on week-off energy restriction pattern, were selected for analysis. FGF-21 levels were not altered by weight loss and were not correlated with body weight or BMI at baseline or 12 months. Weight loss after 12 months either through continuous energy restriction or intermittent energy restriction was -5.9 +/- 4.5 and -4.9 +/- 3.4 kg, respectively. There was no change in FGF-21 levels, 0.3 +/- 0.9 and 0.04 +/- 0.2 ng/mL (p = 0.2). In conclusion, weight loss in healthy overweight or obesity subjects did not affect FGF-21 levels.
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页数：5
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