Childhood Ovarian Juvenile Granulosa Cell Tumor: A Retrospective Study With 3 Cases Including Clinical Features, Pathologic Results, and Therapies

Ovarian juvenile granulosa cell tumor (JGCT) is an extremely rare sex cord-stromal tumor that is most commonly encountered in prepubertal girls and young women. In this study, 3 cases of childhood JGCT are reported. The main causes of hospitalization were abnormal abdominal signs and syndromes. Imaging findings indicated masses with multiple cysts and solid components in the abdominal cavities. Diagnosis was confirmed by histopathology. Tumors were excised completely, and all cases have a good outcome in the follow-up (2 to 13 y) without any adjuvant chemotherapy or radiotherapy. This data suggests that children with JGCT might have a variety of initial clinical manifestations. Pathologic examination especially immunohistochemical staining could help to diagnose JGCT. For children, adjuvant treatment may not be necessary if the tumor can be excised completely in early stage.