Combinatorial Synthesis of 3,5-Dimethylene Substituted 1,2,4-Triazoles

被引：0

作者：

Woodard, Scott S. ^{[1
]}

Jerome, Kevin D. ^{[1
]}

机构：

[1] Pfizer Inc, Global Res & Dev, Med & Parallel Chem, Chesterfield, MO 63017 USA

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2011年 / 14卷 / 02期

关键词：

Cyclizations; combinatorial chemistry; 1,2,4-triazoles; Pinner reaction; hydrazides; imidates; 3,5-DISUBSTITUTED 1,2,4-TRIAZOLES; MIT IMIDSAUREESTERN; ANTIBACTERIAL; CYCLIZATION; ANTAGONISTS; AGENTS; ROUTE;

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4-trizoles. [GRAPHICS] .

引用

页码：132 / 137

页数：6

共 35 条

[1]

Al-Masoudi I., 2006, CHEM HETEROCYC COMPO, V42, P1377, DOI [https://doi.org/10.1007/s10593-006-0255-3, DOI 10.1007/S10593-006-0255-3]

[2] Synthesis and SAR evaluation of 1,2,4-triazoles as A2A receptor antagonists [J].

Alanine, A ;

Anselm, L ;

Steward, L ;

Thomi, S ;

Vifian, W ;

Groaning, MD .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (03) :817-821

[3]

[Anonymous], SCI PHAM

[4] A green and facile route to γ- and δ-lactones via efficient Pinner-cyclization of hydroxynitriles in water [J].

Aplander, K ;

Hidestål, O ;

Katebzadeh, K ;

Lindström, UM .

GREEN CHEMISTRY, 2006, 8 (01) :22-24

[5] SYNTHESIS OF 3,5-DISUBSTITUTED 1,2,4-TRIAZOLES CONTAINING TRIMETHOXYPHENYL GROUPS - POTENTIAL ANTAGONISTS OF PLATELET-ACTIVATING-FACTOR [J].

ARES, JJ ;

MESSIER, RJ ;

KORNECKI, E .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1991, 28 (05) :1197-1201

[6] 4-TRIFLUOROMETHYLIMIDAZOLES AND 5-(4-PYRIDYL)-1,2,4-TRIAZOLES, NEW CLASSES OF XANTHINE-OXIDASE INHIBITORS [J].

BALDWIN, JJ ;

KASINGER, PA ;

NOVELLO, FC ;

SPRAGUE, JM ;

DUGGAN, DE .

JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (09) :895-900

[7] Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities [J].

Bayrak, Hacer ;

Demirbas, Ahmet ;

Karaoglu, Senguel Alpay ;

Demirbas, Neslihan .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (03) :1057-1066

[8] An improved procedure for the deamination of symmetrical 3,5-disubstituted 4-amino-1,2,4-triazoles [J].

Bentiss, F ;

Lagrenée, M ;

Vezin, H ;

Bouanis, M ;

Mernari, B .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2002, 39 (01) :93-96

[9] ENZYMATISCHE PEPTIDSYNTHESE .3. PEPTIDBILDUNG AUS DL-THREONIN-ISOPROPYLESTER [J].

BRENNER, M ;

SAILER, E ;

RUFENACHT, K .

HELVETICA CHIMICA ACTA, 1951, 34 (06) :2096-2102

[10] TRIAZOLES .7. SYNTHESES OF SUBSTITUTED 1,2,4-TRIAZOLES [J].

BROWNE, EJ ;

POLYA, JB .

JOURNAL OF THE CHEMICAL SOCIETY, 1962, (DEC) :5149-&

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