In vitro properties of PLLA screws and novel bioabsorbable implant with elastic nucleus to replace intervertebral disc

被引：16

作者：

Ellä, V ^{[1
]}

Kellomäki, M ^{[1
]}

Törmälä, P ^{[1
]}

机构：

[1] Tampere Univ Technol, Inst Biomat, FIN-33101 Tampere, Finland

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2005年 / 16卷 / 07期

基金：

芬兰科学院;

关键词：

D O I：

10.1007/s10856-005-2537-1

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The suitability of two different implant types for the replacement of the intervertebral disc was studied in vitro. Self-reinforced poly-L-lactide (SR-PLLA) screws empty set 4.5 mm were studied 24 weeks in vitro and cylindrical implants with elastic nucleus made of poly(L/D)lactide 96/4, poly(L/DL)lactide 70/30, Bioactive Glass n:o 13-93 and Polyactive(R) 100OPEOT70PBT30 were studied 15 weeks in vitro. The cylindrical implant mimics the size and shape of the intervertebral disc. During the in vitro, there were no changes in compression properties with either implant types. The screws had sufficient modulus for intervertebral ossification in the canine model and the cylindrical implant showed also sufficient mechanical properties. These results suggest that both implant types could be used in clinical testing. (C) 2005 Springer Science + Business Media, Inc.

引用

页码：655 / 662

页数：8

共 30 条

[1] Composite hydrogels for intervertebral disc prostheses [J].

Ambrosio, L ;

Netti, PA ;

Iannace, S ;

Huang, SJ ;

Nicolais, L .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1996, 7 (05) :251-254

[2] The artificial disc: Theory, design and materials [J].

Bao, QB ;

McCullen, GM ;

Higham, PA ;

Dumbleton, JH ;

Yuan, HA .

BIOMATERIALS, 1996, 17 (12) :1157-1167

[3]

BEDZINSKI R, 1997, BIOMECHANICA INZYNIE, P100

[4]

Bruneau M, 2001, NEUROSURG FOCUS, V10, pE8

[5] THE ANTERIOR APPROACH FOR REMOVAL OF RUPTURED CERVICAL DISKS [J].

CLOWARD, RB .

JOURNAL OF NEUROSURGERY, 1958, 15 (06) :602-617

[6]

FAGER CA, 1989, ATLAS SPINE SURG, P3

[7] INVESTIGATION OF STRUCTURE OF SOLUTION GROWN CRYSTALS OF LACTIDE COPOLYMERS BY MEANS OF CHEMICAL-REACTIONS [J].

FISCHER, EW ;

STERZEL, HJ ;

WEGNER, G .

KOLLOID-ZEITSCHRIFT AND ZEITSCHRIFT FUR POLYMERE, 1973, 251 (11) :980-990

[8]

FRASER RD, 1995, SPINE, V20, P1675

[9]

Gan JC, 2000, J BIOMED MATER RES, V51, P596, DOI 10.1002/1097-4636(20000915)51:4<596::AID-JBM7>3.0.CO

[10]

2-O

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