Effect of mesenchymal stem cell in liver regeneration and clinical applications

被引:13
作者
Lee, Seong Min [1 ]
Lee, Seung Duk [2 ]
Wang, Sarah Ziqi [1 ]
Sarkar, Devanand [3 ]
Lee, Hannah M. [4 ]
Khan, Aamir [2 ]
Bhati, Chandra [2 ]
Sharma, Amit [2 ]
Kumaran, Vinay [2 ]
Bruno, David [2 ]
Cotterell, Adrian [2 ]
Levy, Marlon F. [2 ]
机构
[1] Virginia Commonwealth Univ, Sch Med, Richmond, VA 23298 USA
[2] Virginia Commonwealth Univ, Div Transplant Surg, Dept Surg, Richmond, VA 23298 USA
[3] Virginia Commonwealth Univ, Sch Med, Dept Human & Mol Genet, Richmond, VA 23298 USA
[4] Virginia Commonwealth Univ, Div Gastroenterol Hepatol & Nutr, Richmond, VA 23298 USA
关键词
Mesenchymal stem cell; liver regeneration; end-stage liver disease; HEPATIC STELLATE CELLS; BONE-MARROW-CELLS; OXIDATIVE STRESS; PROGENITOR CELLS; IN-VIVO; CARBON-TETRACHLORIDE; ADIPOSE-TISSUE; GROWTH-FACTOR; RAT-LIVER; HEPATOCELLULAR-CARCINOMA;
D O I
10.20517/2394-5079.2021.07
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Liver disease accounts for approximately 2 million deaths per year worldwide with cirrhosis, viral hepatitis, and malignancy being the most common causes. Consequently, the regenerative capacity of the liver is a topic of extreme interest in the search for curative therapies to end-stage liver disease. Mesenchymal stem cells (MSCs) have emerged as a promising new therapy for hepatic regeneration. MSCs have multiple properties that make them an appropriate treatment option for liver disease including easy accessibility, targeted migration, immunomodulatory potential and antifibrotic/antioxidant effects. Additionally, MSCs have potential clinical applications in acellular therapy and tissue engineering. Liver regeneration with concurrent attenuation of liver injury makes MSCs a compelling therapeutic target in the setting of severe liver disease. This review outlines the mechanisms of MSC-driven liver regeneration and suggests potential clinical applications.
引用
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页数:19
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