MHC class I receptors on natural killer cells: on with the old and in with the new

被引：5

作者：

Khakoo, SI ^{[1
]}

Brooks, CR ^{[1
]}

机构：

[1] Univ Southampton, Sch Med, Div Infect Inflammat & Repair, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England

来源：

CLINICAL SCIENCE | 2003年 / 105卷 / 02期

关键词：

C-type lectin-like receptors; evolution; killer cell Ig-like receptor; MHC class I; natural killer cells;

D O I：

10.1042/CS20030095

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The functions of natural killer (NK) cells are controlled by an abundance of activating and inhibitory receptors. Many of these interact with MHC class I molecules. The MHC system also interacts with cytotoxic T-lymphocytes and has been shown to comprise a-rapidly evolving family of molecules. This challenges the functional relationship of NK cell receptors with their ligands. Although individual receptors have become subject to species-specific expansions over evolutionary time, the main themes of the NK cell interaction with MHC class I have been preserved. This review details the interaction of NK cell receptors with MHC class I and discusses their unexpectedly rapid evolution.

引用

页码：127 / 140

页数：14

共 129 条

[31] Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants [J].