FULVIC ACID COATED IRON OXIDE NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING CONTRAST AGENT

被引：8
|
作者：
Zhou, Chunjiao [2 ]
Rong, Pengfei [1 ]
Zhang, Wenjie [2 ]
Zhou, Jianda [1 ]
Zhang, Qinglin [2 ]
Wang, Wei [1 ]
Zou, Bingsuo [2 ,3 ]
机构：
[1] Cent S Univ, Xiang Ya Hosp 3, Dept Radiol, Changsha 410013, Hunan, Peoples R China
[2] Hunan Univ, Micronano Ctr, State Key Lab CSBC, Changsha 410082, Hunan, Peoples R China
[3] Beijing Inst Technol, Sch MSE, Beijing 100081, Peoples R China
来源：
FUNCTIONAL MATERIALS LETTERS | 2010年 / 3卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Superparamagnetic; iron oxide; fulvic acid; MRI; NANOCRYSTALS;
D O I：
10.1142/S179360471000124X
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Fulvic acid coated Fe3O4 superparamagnetic nanoparticles were synthesized by a coprecipitation technique with iron salts and a small molecule stabilizer-fulvic acid. The prepared nanoparticles were well dispersed in water with about 10nm in size according to transmission electron microscopy (TEM) observations. Fourier transform infrared spectroscopy (FTIR) revealed that fulvic acid were successfully covalently bonded to Fe3O4 through the two adjacent phenolic hydroxyl groups and the carboxyl (-COOH) groups were functionalized to the surface. The vibrating sample magnetometer (VSM) result showed that the nanoparticles were superparamagnetic and the saturation magnetizations were 60emu/g. Moreover, their efficacy of liver magnetic resonance imaging (MRI) contrast agent was investigated by using live rat and tumor-bearing rabbit models through conventional clinical 1.5T MRI.
引用
收藏
页码：197 / 200
页数：4
相关论文
共 50 条
  • [41] Superparamagnetic iron oxide particles: contrast media for magnetic resonance imaging
    Lawaczeck, R
    Menzel, M
    Pietsch, H
    APPLIED ORGANOMETALLIC CHEMISTRY, 2004, 18 (10) : 506 - 513
  • [42] Designed synthesis of uniformly sized iron oxide nanoparticles for efficient magnetic resonance imaging contrast agents
    Lee, Nohyun
    Hyeon, Taeghwan
    CHEMICAL SOCIETY REVIEWS, 2012, 41 (07) : 2575 - 2589
  • [43] Uniform mesoporous silica coated iron oxide nanoparticles as a highly efficient, nontoxic MRI T2 contrast agent with tunable proton relaxivities
    Ye, Fei
    Laurent, Sophie
    Fornara, Andrea
    Astolfi, Laura
    Qin, Jian
    Roch, Alain
    Martini, Alessandro
    Toprak, Muhammet S.
    Muller, Robert N.
    Muhammed, Mamoun
    CONTRAST MEDIA & MOLECULAR IMAGING, 2012, 7 (05) : 460 - 468
  • [44] Poly(amino acid)-coated iron oxide nanoparticles as ultra-small magnetic resonance probes
    Yang, Hee-Man
    Lee, Hyun Jin
    Jang, Kwang-Suk
    Park, Chan Woo
    Yang, Hee Won
    Do Heo, Won
    Kim, Jong-Duk
    JOURNAL OF MATERIALS CHEMISTRY, 2009, 19 (26) : 4566 - 4574
  • [45] Zinc-Nickel Ferrite Nanoparticles as a Contrast Agent in Magnetic Resonance Imaging
    Sattarahmady, N.
    Heidari, M.
    Zare, T.
    Lotfi, M.
    Heli, H.
    APPLIED MAGNETIC RESONANCE, 2016, 47 (08) : 925 - 935
  • [46] Rapid microwave-assisted synthesis of dextran-coated iron oxide nanoparticles for magnetic resonance imaging
    Osborne, Elizabeth A.
    Atkins, Tonya M.
    Gilbert, Dustin A.
    Kauzlarich, Susan M.
    Liu, Kai
    Louie, Angelique Y.
    NANOTECHNOLOGY, 2012, 23 (21)
  • [47] Synthesis and characterization of silica-embedded iron oxide nanoparticles for magnetic resonance imaging
    Yan, F
    Xu, H
    Anker, J
    Kopelman, R
    Ross, B
    Rehemtulla, A
    Reddy, R
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2004, 4 (1-2) : 72 - 76
  • [48] Mono and dialkoxysilane surface modification of superparamagnetic iron oxide nanoparticles for application as magnetic resonance imaging contrast agents
    Larsen, Brian A.
    Hurst, Kendall M.
    Ashurst, W. Robert
    Serkova, Natalie J.
    Stoldt, Conrad R.
    JOURNAL OF MATERIALS RESEARCH, 2012, 27 (14) : 1846 - 1852
  • [49] Silica Coated Iron/Iron Oxide Nanoparticles as a Nano-Platform for T2 Weighted Magnetic Resonance Imaging
    Mathieu, Paul
    Coppel, Yannick
    Respaud, Marc
    Nguyen, Quyen T.
    Boutry, Sebastien
    Laurent, Sophie
    Stanicki, Dimitri
    Henoumont, Celine
    Novio, Fernando
    Lorenzo, Julia
    Montpeyo, David
    Amiens, Catherine
    MOLECULES, 2019, 24 (24):
  • [50] Magnetic resonance imaging using heparin-coated superparamagnetic iron oxide nanoparticles for cell tracking in vivo
    Hwang, Yong Hwa
    Lee, Dong Yun
    QUANTITATIVE IMAGING IN MEDICINE AND SURGERY, 2012, 2 (02) : 118 - 123
12345