FULVIC ACID COATED IRON OXIDE NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING CONTRAST AGENT

被引：8
|
作者：
Zhou, Chunjiao [2 ]
Rong, Pengfei [1 ]
Zhang, Wenjie [2 ]
Zhou, Jianda [1 ]
Zhang, Qinglin [2 ]
Wang, Wei [1 ]
Zou, Bingsuo [2 ,3 ]
机构：
[1] Cent S Univ, Xiang Ya Hosp 3, Dept Radiol, Changsha 410013, Hunan, Peoples R China
[2] Hunan Univ, Micronano Ctr, State Key Lab CSBC, Changsha 410082, Hunan, Peoples R China
[3] Beijing Inst Technol, Sch MSE, Beijing 100081, Peoples R China
来源：
FUNCTIONAL MATERIALS LETTERS | 2010年 / 3卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Superparamagnetic; iron oxide; fulvic acid; MRI; NANOCRYSTALS;
D O I：
10.1142/S179360471000124X
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Fulvic acid coated Fe3O4 superparamagnetic nanoparticles were synthesized by a coprecipitation technique with iron salts and a small molecule stabilizer-fulvic acid. The prepared nanoparticles were well dispersed in water with about 10nm in size according to transmission electron microscopy (TEM) observations. Fourier transform infrared spectroscopy (FTIR) revealed that fulvic acid were successfully covalently bonded to Fe3O4 through the two adjacent phenolic hydroxyl groups and the carboxyl (-COOH) groups were functionalized to the surface. The vibrating sample magnetometer (VSM) result showed that the nanoparticles were superparamagnetic and the saturation magnetizations were 60emu/g. Moreover, their efficacy of liver magnetic resonance imaging (MRI) contrast agent was investigated by using live rat and tumor-bearing rabbit models through conventional clinical 1.5T MRI.
引用
收藏
页码：197 / 200
页数：4
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