Skeletal diversity by sequential one-pot and stepwise routes using morpholine ester scaffolds

被引：25

作者：

Ciofi, Leonardo ^{[1
]}

Morvillo, Manfredi ^{[1
]}

Sladojevich, Filippo ^{[2
]}

Guarna, Antonio ^{[1
]}

Trabocchi, Andrea ^{[1
]}

机构：

[1] Univ Florence, Dept Chem Ugo Schiff, I-50019 Florence, Italy

[2] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 48期

关键词：

Chemical diversity; Amino acids; Peptidomimetics; Combinatorial Chemistry; Heterocycles; SMALL MOLECULES; DERIVATIVES; DIKETOPIPERAZINE; 3-COMPONENT; ALKYLATION; INHIBITORS; ACCESS; AGENT;

D O I：

10.1016/j.tetlet.2010.09.103

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A skeletal diversity approach starting from morpholine acetals has been achieved by tuning a three-step process from stepwise to sequential one-pot to provide diverse scaffolds containing either a 2-oxopiperazine or a diketopiperazine skeleton. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6282 / 6285

页数：4

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