CX-4945: the protein kinase CK2 inhibitor and anti-cancer drug shows anti-fungal activity

被引：12
作者：
Masyk, Maciej [1 ]
Janeczko, Monika [1 ]
Martyna, Aleksandra [1 ]
Kubinski, Konrad [1 ]
机构：
[1] John Paul II Catholic Univ Lublin, Inst Biotechnol, Dept Mol Biol, Ul Konstantynow 1i, PL-20708 Lublin, Poland
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2017年 / 435卷 / 1-2期
关键词：
CX-4945; Protein kinase CK2; Yeast; Antifungal agents; Antitumor agents; CANDIDA-ALBICANS; SACCHAROMYCES-CEREVISIAE; GROWTH; CANCER; MUTANTS;
D O I：
10.1007/s11010-017-3068-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
CX-4945 is a selective inhibitor of protein kinase CK2 exhibiting clinical significance. Its antitumor properties arise from the abrogation of CK2-mediated pro-survival cellular pathways. The presented data reveal the influence of CX-4945 on the growth of yeast cells showing variable potency against Saccharomyces cerevisiae deletion strains with different contents of CK2 subunits. The catalytic subunit CK2 alpha appears to sensitize yeast to the CX-4945 action. Moreover, the compound suppresses hyphal growth and cell adhesion of Candida albicans, thereby abolishing some hallmarks of invasiveness of the pathogen. It is known that cancer patients are more prone to fungal infections. Our data unveil the dual-activity of CX-4945; when used in anti-cancer therapy, it may simultaneously prevent cancer-associated candidiasis.
引用
收藏
页码：193 / 196
页数：4
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