Biomaterial-Assisted Regenerative Medicine

被引:62
作者
Nii, Teruki [1 ,2 ]
Katayama, Yoshiki [1 ,2 ,3 ,4 ,5 ]
机构
[1] Kyushu Univ, Fac Engn, Dept Appl Chem, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan
[2] Kyushu Univ, Grad Sch Syst Life Sci, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan
[3] Kyushu Univ, Ctr Future Chem, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan
[4] Kyushu Univ, Int Res Ctr Mol Syst, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan
[5] Chung Yuan Christian Univ, Dept Biomed Engn, 200 Chung Pei Rd, Chungli 32023, Taiwan
关键词
regenerative medicine; biomaterials; cell transplantation; tissue engineering; drug research; MESENCHYMAL STEM-CELLS; CANCER-ASSOCIATED FIBROBLASTS; GELATIN HYDROGEL; MECHANICAL-PROPERTIES; IN-VITRO; TUMOR MICROENVIRONMENT; ALGINATE MICROSPHERES; COMPOSITE SCAFFOLDS; COLLAGEN SCAFFOLDS; CULTURE-SYSTEM;
D O I
10.3390/ijms22168657
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review aims to show case recent regenerative medicine based on biomaterial technologies. Regenerative medicine has arousing substantial interest throughout the world, with "The enhancement of cell activity" one of the essential concepts for the development of regenerative medicine. For example, drug research on drug screening is an important field of regenerative medicine, with the purpose of efficient evaluation of drug effects. It is crucial to enhance cell activity in the body for drug research because the difference in cell condition between in vitro and in vivo leads to a gap in drug evaluation. Biomaterial technology is essential for the further development of regenerative medicine because biomaterials effectively support cell culture or cell transplantation with high cell viability or activity. For example, biomaterial-based cell culture and drug screening could obtain information similar to preclinical or clinical studies. In the case of in vivo studies, biomaterials can assist cell activity, such as natural healing potential, leading to efficient tissue repair of damaged tissue. Therefore, regenerative medicine combined with biomaterials has been noted. For the research of biomaterial-based regenerative medicine, the research objective of regenerative medicine should link to the properties of the biomaterial used in the study. This review introduces regenerative medicine with biomaterial.
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页数:18
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