Social touch modulates endogenous μ-opioid system activity in humans

被引：121

作者：

Nummenmaa, Lauri ^{[1
,3
]}

Tuominen, Lauri ^{[3
]}

Dunbar, Robin ^{[1
,4
]}

Hirvonen, Jussi ^{[3
]}

Manninen, Sandra ^{[1
]}

Arponen, Eveliina ^{[3
]}

Machin, Anna ^{[4
]}

Hari, Riitta ^{[2
]}

Jaaskelainen, Iiro P. ^{[1
]}

Sams, Mikko ^{[1
]}

机构：

[1] Aalto Univ, Sch Sci, Dept Neurosci & Biomed Engn, FI-00076 Aalto, Finland

[2] Aalto Univ, Sch Arts Design & Architecture, Dept Art, FI-00076 Aalto, Finland

[3] Univ Turku, Turku PET Ctr, FIN-20520 Turku, Finland

[4] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England

来源：

NEUROIMAGE | 2016年 / 138卷

基金：

芬兰科学院; 欧洲研究理事会;

关键词：

Bonding; PET; Opioids; Touching; Somatosensory; RECEPTOR GENE OPRM1; ATTACHMENT BEHAVIOR; RESPONSES; BRAIN; PAIN; AVAILABILITY; AFFERENTS; REJECTION; PRIMATES; MORPHINE;

D O I：

10.1016/j.neuroimage.2016.05.063

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In non-human primates, opioid-receptor blockade increases social grooming, and the endogenous opioid system has therefore been hypothesized to support maintenance of long-term relationships in humans as well. Here we tested whether social touch modulates opioidergic activation in humans using in vivo positron emission tomography (PET). Eighteen male participants underwent two PET scans with [11C] carfentanil, a ligand specific to mu-opioid receptors (MOR). During the social touch scan, the participants lay in the scanner while their partners caressed their bodies in a non-sexual fashion. In the baseline scan, participants lay alone in the scanner. Social touch triggered pleasurable sensations and increased MOR availability in the thalamus, striatum, and frontal, cingulate, and insular cortices. Modulation of activity of the opioid system by social touching might provide a neurochemical mechanism reinforcing social bonds between humans. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：242 / 247

页数：6

共 56 条

[41] ENDOGENOUS OPIOIDS AND SOCIAL-BEHAVIOR [J].

PANKSEPP, J ;

HERMAN, BH ;

VILBERG, T ;

BISHOP, P ;

DEESKINAZI, FG .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1980, 4 (04) :473-487

[42] The characteristics of heroin users entering treatment: findings from the Australian Treatment Outcome Study (ATOS) [J].

Ross, J ;

Teesson, M ;

Darke, S ;

Lynskey, M ;

Ali, R ;

Ritter, A ;

Cooke, R .

DRUG AND ALCOHOL REVIEW, 2005, 24 (05) :411-418

[43]

Saarimaki H., 2015, CEREB CORTEX, pbhv086

[44]

Sander C.Y., 2014, 10 INT S FUNCT NEUR

[45] Empathy for pain involves the affective but not sensory components of pain [J].

Singer, T ;

Seymour, B ;

O'Doherty, J ;

Kaube, H ;

Dolan, RJ ;

Frith, CD .

SCIENCE, 2004, 303 (5661) :1157-1162

[46] Topography of social touching depends on emotional bonds between humans [J].

Suvilehto, Juulia T. ;

Glerean, Enrico ;

Dunbar, Robin I. M. ;

Hari, Riitta ;

Nummenmaa, Lauri .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (45) :13811-13816

[47] Nucleus Accumbens μ-Opioid Receptors Mediate Social Reward [J].

Trezza, Viviana ;

Damsteegt, Ruth ;

Achterberg, E. J. Marijke ;

Vanderschuren, Louk J. M. J. .

JOURNAL OF NEUROSCIENCE, 2011, 31 (17) :6362-6370

[48] Mapping neurotransmitter networks with PET: An example on serotonin and opioid systems [J].

Tuominen, Lauri ;

Nummenmaa, Lauri ;

Keltikangas-Jarvinen, Liisa ;

Raitakari, Olli ;

Hietala, Jarmo .

HUMAN BRAIN MAPPING, 2014, 35 (05) :1875-1884

[49] Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain [J].

Tzourio-Mazoyer, N ;

Landeau, B ;

Papathanassiou, D ;

Crivello, F ;

Etard, O ;

Delcroix, N ;

Mazoyer, B ;

Joliot, M .

NEUROIMAGE, 2002, 15 (01) :273-289

[50] Variation in the μ-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection [J].

Way, Baldwin M. ;

Taylor, Shelley E. ;

Eisenberger, Naomi I. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (35) :15079-15084

← 1 2 3 4 5 6 →