Social touch modulates endogenous μ-opioid system activity in humans

被引:121
作者
Nummenmaa, Lauri [1 ,3 ]
Tuominen, Lauri [3 ]
Dunbar, Robin [1 ,4 ]
Hirvonen, Jussi [3 ]
Manninen, Sandra [1 ]
Arponen, Eveliina [3 ]
Machin, Anna [4 ]
Hari, Riitta [2 ]
Jaaskelainen, Iiro P. [1 ]
Sams, Mikko [1 ]
机构
[1] Aalto Univ, Sch Sci, Dept Neurosci & Biomed Engn, FI-00076 Aalto, Finland
[2] Aalto Univ, Sch Arts Design & Architecture, Dept Art, FI-00076 Aalto, Finland
[3] Univ Turku, Turku PET Ctr, FIN-20520 Turku, Finland
[4] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England
基金
芬兰科学院; 欧洲研究理事会;
关键词
Bonding; PET; Opioids; Touching; Somatosensory; RECEPTOR GENE OPRM1; ATTACHMENT BEHAVIOR; RESPONSES; BRAIN; PAIN; AVAILABILITY; AFFERENTS; REJECTION; PRIMATES; MORPHINE;
D O I
10.1016/j.neuroimage.2016.05.063
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In non-human primates, opioid-receptor blockade increases social grooming, and the endogenous opioid system has therefore been hypothesized to support maintenance of long-term relationships in humans as well. Here we tested whether social touch modulates opioidergic activation in humans using in vivo positron emission tomography (PET). Eighteen male participants underwent two PET scans with [11C] carfentanil, a ligand specific to mu-opioid receptors (MOR). During the social touch scan, the participants lay in the scanner while their partners caressed their bodies in a non-sexual fashion. In the baseline scan, participants lay alone in the scanner. Social touch triggered pleasurable sensations and increased MOR availability in the thalamus, striatum, and frontal, cingulate, and insular cortices. Modulation of activity of the opioid system by social touching might provide a neurochemical mechanism reinforcing social bonds between humans. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:242 / 247
页数:6
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