Stereoselective and facile total synthesis of (+)-goniodiol, a styryllactone from carbohydrates

被引：16
|
作者：
Yadav, Jhillu Singh [1 ]
Das, Saibal [1 ]
Mishra, Anand Kumar [1 ]
机构：
[1] Indian Inst Chem Technol CSIR, Div Organ Chem 1, Hyderabad 500607, Andhra Pradesh, India
来源：
TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 20期
关键词：
STYRYL-LACTONES; (+)-9-DEOXYGONIOPYPYRONE; (+)-ALTHOLACTONE; (+)-8-ACETYLGONIOTRIOL; 8-METHOXYGONIODIOL; (+)-GONIOFUFURONE; (+)-GONIOPYPYRONE; CYTOTOXICITY; DERIVATIVES; GONIODIOL;
D O I：
10.1016/j.tetasy.2010.08.017
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The stereoselective synthesis of (+)-goniodiol a cytotoxic styryllactone has been accomplished in 10 steps starting from inexpensive and readily available D-manitol and delta-gluconolactone involving the direct and straightforward reaction conditions of Grignard addition chain elongation and hydroboration thus making the synthesis simple and convenient (C) 2010 Published by Elsevier Ltd
引用
收藏
页码：2443 / 2447
页数：5
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