Neurodevelopmental outcome in 7-year-old children is not affected by exercise during pregnancy: follow up of a multicentre randomised controlled trial

被引:16
作者
Ellingsen, M. S. [1 ]
Pettersen, A. [1 ]
Stafne, S. N. [2 ,3 ]
Morkved, S. [2 ,3 ]
Salvesen, K. A. [4 ,5 ]
Evensen, K. A., I [4 ,6 ]
机构
[1] Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Trondheim, Norway
[2] Norwegian Univ Sci & Technol NTNU, Dept Publ Hlth & Nursing, Trondheim, Norway
[3] Trondheim Reg & Univ Hosp, St Olavs Hosp, Clin Clin Serv, Trondheim, Norway
[4] Norwegian Univ Sci & Technol NTNU, Dept Clin & Mol Med, POB 8905, NO-7491 Trondheim, Norway
[5] Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Obstet & Gynecol, Trondheim, Norway
[6] Oslo Metropolitan Univ, Dept Physiotherapy, Oslo, Norway
关键词
Behavioural problems; child; cognitive skills; emotional problems; exercise during pregnancy; follow up; language skills; motor skills; neurodevelopment; randomised controlled trial; social skills; PHYSICAL-ACTIVITY; FTF; 5; PRENATAL EXERCISE; REGULAR EXERCISE; 15; QUESTIONNAIRE; PRETERM BIRTH; WEIGHT-GAIN; WOMEN; METAANALYSIS; GROWTH;
D O I
10.1111/1471-0528.16024
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective To investigate whether regular moderate intensity exercise during pregnancy had adverse effects on neurodevelopment of offspring at 7 years of age. Design Follow up of a multicentre randomised controlled trial. Setting St Olav's Hospital, Trondheim University Hospital and Stavanger University Hospital, Norway (2007-09). Population Women randomised to follow a 12-week structured exercise protocol or standard antenatal care during pregnancy. Methods At 7 years of age, neurodevelopmental outcome was assessed by the parent questionnaire Five-To-Fifteen (FTF), including motor skills, executive functions, perception, memory, language, social skills and possible emotional/behavioural problems. Main outcome measure Continuous and dichotomised (cut-off 90th centile) FTF scores. Results A total of 855 women were randomised to exercise (n = 429) or standard antenatal care (n = 426) during pregnancy. At follow up, 164 (38.2%) children born to mothers in the intervention group and 115 (27.0%) children born to mothers in the control group participated. We found no group differences in FTF scores or in the proportion of children with scores >= 90th centile. Stratified analyses by sex, subgroup analyses of women who adhered to the exercise protocol or sensitivity analyses excluding preterm children and/or children who had been admitted to the neonatal intensive care unit did not change the results. Conclusions In the present randomised controlled trial follow-up study, regular moderate intensity exercise during pregnancy did not have adverse effects on neurodevelopment of offspring at 7 years of age. Tweetable abstract Moderate intensity exercise during pregnancy had no adverse effects on neurodevelopment of offspring at 7 years of age.
引用
收藏
页码:508 / 517
页数:10
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