Electrodeposition on Nanofibrous Polymer Scaffolds: Rapid Mineralization, Tunable Calcium Phosphate Composition and Topography

被引：85
作者：
He, Chuanglong [1 ,3 ]
Xiao, Guiyong [1 ]
Jin, Xiaobing [1 ]
Sun, Chenghui [1 ]
Ma, Peter X. [1 ,2 ]
机构：
[1] Univ Michigan, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Biomed Engn, Macromol Sci & Engn Ctr, Ann Arbor, MI 48109 USA
[3] Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Coll Chem & Chem Engn & Biol Engn, Shanghai 201620, Peoples R China
来源：
ADVANCED FUNCTIONAL MATERIALS | 2010年 / 20卷 / 20期
基金：
美国国家卫生研究院;
关键词：
ELECTROCHEMICAL DEPOSITION; COATINGS; HYDROXYAPATITE; TITANIUM; ELECTROCRYSTALLIZATION; DIFFERENTIATION; NANOCOMPOSITES; BIOMATERIALS; ELECTROLYTE; FABRICATION;
D O I：
10.1002/adfm.201000993
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A straightforward, fast and versatile technique to fabricate mineralized nanofibrous polymer scaffolds for bone regeneration is developed. Nanofibrous poly(L-lactic acid) scaffolds are fabricated using both electrospinning and phase separation techniques. An electrodeposition process is designed to deposit calcium phosphate on the nanofibrous scaffolds. Such scaffolds contain a high quality mineral coating on the fiber surface and have surface topography and chemical composition that are tunable by varying the processing parameters. These scaffolds can mimic the composition and structure of the natural bone extracellular matrix and provide a more biocompatible interface for bone regeneration.
引用
收藏
页码：3568 / 3576
页数：9
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