Sex Steroids Affect Triglyceride Handling, Glucose-Dependent Insulinotropic Polypeptide, and Insulin Sensitivity

被引：25

作者：

Lapauw, Bruno ^{[1
]}

Ouwens, Margriet ^{[3
]}

't Hart, Leen M. ^{[4
]}

Wuyts, Birgitte ^{[2
]}

Holst, Jens J. ^{[5
]}

T'Sjoen, Guy ^{[1
]}

Kaufman, Jean-Marc ^{[1
]}

Ruige, Johannes B. ^{[1
]}

机构：

[1] Ghent Univ Hosp, Dept Endocrinol, B-9000 Ghent, Belgium

[2] Ghent Univ Hosp, Lab Metab Dis, B-9000 Ghent, Belgium

[3] Deutsch Diabet Zentrum, Inst Klin Biochem & Pathobiochem, Dusseldorf, Germany

[4] Leiden Univ, Med Ctr, Dept Mol Cell Biol, Leiden, Netherlands

[5] Univ Copenhagen, Panum Inst, Dept Biomed Sci, DK-2200 Copenhagen, Denmark

来源：

DIABETES CARE | 2010年 / 33卷 / 08期

关键词：

LOW SERUM TESTOSTERONE; METABOLIC SYNDROME; MEN; PREDICTION; HORMONES; GIP;

D O I：

10.2337/dc10-0515

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE- To evaluate metabolic effects of sex steroids in nonfasting and fasting conditions, independent from changes in body composition. RESEARCH DESIGN AND METHODS- A randomized clinical trial was performed to create contrasting sex steroid levels in healthy young men: by letrozole (aromatase inhibitor) to lower estradiol (E-2) and increase testosterone (group T, n = 10) versus letrozole plus E-2 patches to lower T and raise E-2 (group E, n = 10). Mixed meals and hyperinsulinemic-euglycemic clamps were performed before and after a 1-week treatment period. RESULTS- Following intervention, the postprandial triglyceride response displayed a diverging response with a decline in group T and an increase in group E; the postprandial glucose-dependent insulinotropic polypeptide (GIP) response increased in group T. Insulin sensitivity increased in group T but remained unaltered in group E. CONCLUSIONS- In healthy young men, short-term changes in sex steroids affect postprandial triglyceride and GIP response and insulin sensitivity.

引用

页码：1831 / 1833

页数：3

共 15 条

[1] Low serum testosterone in men is inversely associated with non-fasting serum triglycerides:: The Tromso study [J].