Effect of ACTH-induced hypercortisolemia on the EEG in patients with stress-related epilepsy

被引:2
作者
Klein, P [1 ]
Sahoo, S [1 ]
机构
[1] Georgetown Univ Hosp, Washington, DC 20007 USA
关键词
epilepsy; seizures; stress; cortisol; neurosteroids; adrencorticotrophic hormone; cosyntropin; hypercortisolemia; epileptiform;
D O I
10.1016/j.yebeh.2004.11.010
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Purpose. We assess the effect of acute hypercortisolemia induced by ACTH stimulation on seizures and EEG interictal spike activity in patients with localization-related epilepsy (LRE) and stress-related seizures. Methods. Seven patients (3 males, 4 females) with LRE and stress-related seizures were studied. All patients underwent ACTH stimulation with 0.25-0.75 mg Cosyntropin intravenously at 8 AM. Serum cortisol and ACTH levels were monitored half- to one-hourly for 4 to 6 hours. Video/EEG monitoring was also performed. Results. ACTH injection induced hypercortisolemia in all patients. Hypercortisolemia was not associated with seizures or interictal spike facilitation in any patient. Two patients experienced seizures on the day of ACTH injection, one 8 hours after and another 15 and 12 hours after the injection, during a period when their cortisol levels had returned to normal. Conclusion. No reproducible interictal EEG changes occurred in any of the patients following ACTH injection. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:187 / 190
页数:4
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