Prediction of Antidepressant Efficacy by Cognitive Function in First-Episode Late-Life Depression: A Pilot Study

被引:8
作者
Pan, Weigang [1 ,2 ,3 ]
Liu, Chaomeng [1 ,2 ,3 ]
Zhu, Dandi [1 ,2 ,3 ]
Liu, Yi [1 ,2 ,3 ]
Mao, Peixian [1 ,2 ,3 ]
Ren, Yanping [1 ,2 ,3 ]
Ma, Xin [1 ,2 ,3 ]
机构
[1] Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
[2] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China
[3] Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
来源
FRONTIERS IN PSYCHIATRY | 2022年 / 13卷
关键词
treatment response; remission; aging population; major depression (MDD); cognitive predictors; cognitive function; NEUROPSYCHOLOGICAL PERFORMANCE; CLINICAL-VARIABLES; TREATMENT RESPONSE; REMISSION; ASSOCIATION; IMPAIRMENT; SYMPTOMS; DISORDER; KETAMINE; MEMORY;
D O I
10.3389/fpsyt.2022.916041
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The response rate of treatment for late-life depression (LLD) is only 25-60%. The cognitive impairment associated with LLD often affects the effectiveness of antidepressants and may has the potential ability to predict response. This study seeks a biomarker for baseline cognitive function to predict efficacy of antidepressants. Sixty patients diagnosed with LLD received escitalopram or sertraline treatment for 8 weeks. Clinical symptom was measured using Hamilton Depression Rating Scale-17 (HAMD-17) and cognitive function was measured using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), Trail Making Test (TMT) before and after 8-week treatment. Patients were divided into treatment effective group (TE) and treatment ineffective group (TI) according to reduction rate in scores of HAMD-17 after treatment. Thirty-eight matched healthy controls (HC) were assessed using RBANS and TMT. There was significant decrease of score of RBANS and increase of score of TMT in patients with LLD compared with HC. Regression analysis revealed that change in HAMD-17 score was significantly positively associated with baseline score of picture naming, figure copy, digit span, and delayed memory. The preliminary findings suggested that working memory, attention, visuospatial, language function, and delayed memory should be examined further as a means of providing the useful objective biomarkers of treatment response.
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页数:8
相关论文
共 44 条
[1]   The global prevalence of major depressive disorder (MDD) among the elderly: A systematic review and meta-analysis [J].
Abdoli, Nasrin ;
Salari, Nader ;
Darvishi, Niloofar ;
Jafarpour, Sima ;
Solaymani, Mina ;
Mohammadi, Masoud ;
Shohaimi, Shamarina .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2022, 132 :1067-1073
[2]   Magnetic Resonance Imaging Predictors of Treatment Response in Late-Life Depression [J].
Aizenstein, Howard J. ;
Khalaf, Alexander ;
Walker, Sarah E. ;
Andreescu, Carmen .
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, 2014, 27 (01) :24-32
[3]   Depression in the elderly [J].
Alexapoulos, GS .
LANCET, 2005, 365 (9475) :1961-1970
[4]  
Alexopoulos George S, 2021, Focus (Am Psychiatr Publ), V19, P340, DOI 10.1176/appi.focus.19304
[5]  
Aziz Rehan, 2017, Focus (Am Psychiatr Publ), V15, P35, DOI 10.1176/appi.focus.20160036
[6]   Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression [J].
Bae, Jae Nam ;
MacFall, James R. ;
Krishnan, K. Ranga R. ;
Payne, Martha E. ;
Steffens, David C. ;
Taylor, Warren D. .
BIOLOGICAL PSYCHIATRY, 2006, 60 (12) :1356-1363
[7]   Cognitive impairment in euthymic major depressive disorder: a meta-analysis [J].
Bora, E. ;
Harrison, B. J. ;
Yuecel, M. ;
Pantelis, C. .
PSYCHOLOGICAL MEDICINE, 2013, 43 (10) :2017-2026
[8]   Executive Functions [J].
Diamond, Adele .
ANNUAL REVIEW OF PSYCHOLOGY, VOL 64, 2013, 64 :135-168
[9]   Does antidepressant therapy improve cognition in elderly depressed patients? [J].
Doraiswamy, PM ;
Krishnan, KRR ;
Oxman, T ;
Jenkyn, LR ;
Coffey, DJ ;
Burt, T ;
Clary, CM .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2003, 58 (12) :1137-1144
[10]   Microvascular Contribution to Late-Onset Depression: Mechanisms, Current Evidence, Association With Other Brain Diseases, and Therapeutic Perspectives [J].
Empana, Jean-Philippe ;
Boutouyrie, Pierre ;
Lemogne, Cedric ;
Jouven, Xavier ;
van Sloten, Thomas T. .
BIOLOGICAL PSYCHIATRY, 2021, 90 (04) :214-225