Production and antiproliferative activity of liposomes containing the antitumour drug chromomycin A3

被引：3

作者：

Cortesi, R ^{[1
]}

Esposito, E ^{[1
]}

Maietti, A ^{[1
]}

Menegatti, E ^{[1
]}

Nastruzzi, C ^{[1
]}

机构：

[1] Univ Ferrara, Dept Pharmaceut Sci, I-44100 Ferrara, Italy

来源：

JOURNAL OF MICROENCAPSULATION | 1998年 / 15卷 / 04期

关键词：

chromomycin; controlled delivery systems; liposomes; antiproliferative activity;

D O I：

10.3109/02652049809006873

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In the present paper the production and characterization of liposomes are described as a specialized drug delivery system for chromomycin. Liposomes were prepared by the reverse phase evaporation technique followed by extrusion through polycarbonate filters; afterwards the vesicles were characterized in terms of dimensions, morphology and encapsulation efficacy. The aim of this work was to produce a drug delivery system able to reduce the toxicity problems related to the administration of this drug. The analysis of the in vitro antiproliferative activity on cultured human leukemic K562 cells demonstrated that ionic and neutral liposomes containing chromomycin are 1.5 and 7-fold more effective respectively as compared to the free drug. Based on these results and taking into account the increased solubility of the drug in this system, liposomes could represent a promising drug delivery system for use in the experimental therapy using chromomycin.

引用

页码：465 / 472

页数：8

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