Colored Potato Extracts Induce Superoxide Dismutase-2 mRNA Via ERK1/2 Pathway in HepG2 Cells

被引：9

作者：

Hashimoto, Naoto ^{[1
,2
]}

Noda, Takahiro ^{[2
]}

Kim, Sun-Ju ^{[2
]}

Yamauchi, Hiroaki ^{[2
]}

Takigawa, Shigenobu ^{[2
]}

Matsuura-Endo, Chie ^{[2
]}

Suzuki, Tatsuro ^{[2
]}

Han, Kyu-Ho ^{[3
]}

Fukushima, Michihiro ^{[3
]}

机构：

[1] Natl Agr Res Ctr Kyushu Okinawa Reg, Kumamoto 8611192, Japan

[2] Natl Agr Res Ctr Hokkaido Reg, Memuro Upland Farming Res Stn, Memuro, Hokkaido 0820081, Japan

[3] Obihiro Univ Agr & Vet Med, Dept Anim Sci, Obihiro, Hokkaido 0808555, Japan

来源：

PLANT FOODS FOR HUMAN NUTRITION | 2010年 / 65卷 / 03期

关键词：

Antioxidant; ERK1/2; HepG2; Shadow Queen; Superoxide dismutase 2; NF-KAPPA-B; INDUCED LIVER-INJURY; TRANSCRIPTIONAL REGULATION; GENE-EXPRESSION; RATS; ACTIVATION; PROTEIN-1; CASCADE; BINDING; HEALTH;

D O I：

10.1007/s11130-010-0171-7

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Rats fed a diet containing Shadow Queen (SQ), an anthocyanin-rich potato cultivar, previously showed an increase in the hepatic superoxide dismutase (SOD)-2 mRNA level. We investigated whether an extract of SQ would directly increase the hepatic SOD-2 mRNA level in HepG2 cells. Furthermore, we estimated the intracellular signaling pathway for the induction of SOD-2 mRNA expression. HepG2 cells were stimulated using extracts of four crops, including SQ, for 12 h; only extracts of colored potatoes induced SOD-2 mRNA expression significantly. This induction of SOD-2 mRNA expression was blocked by an inhibitor of the extracellular signal-related kinase (ERK) 1/2 pathway. Furthermore, an extract of SQ increased the phosphorylation of ERK1/2 after 15 or 30 min of stimulation. These data indicate that an extract of SQ directly induces hepatic SOD-2 mRNA expression via activation of ERK1/2 pathway in HepG2 cells.

引用

页码：266 / 270

页数：5

共 50 条

[41] N-Nitrosopiperidine and N-Nitrosodibutylamine induce apoptosis in HepG2 cells via the caspase dependent pathway
Garcia, Almudena
Morales, Paloma
Rafter, Joseph
Haza, Ana I.
CELL BIOLOGY INTERNATIONAL, 2009, 33 (12) : 1280 - 1286
[42] Embelin-induced apoptosis of HepG2 human hepatocellular carcinoma cells and blockade of HepG2 cells in the G2/M phase via the mitochondrial pathway
Taghiyev, Asaf
Sun, Deguang
Gao, Zhen Ming
Liang, Rui
Wang, Liming
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2012, 4 (04) : 649 - 654
[43] Anti-proliferative effects of recombinant iron superoxide dismutase on HepG2 cells via a redox-dependent PI3k/Akt pathway
Lu, Min
Bi, Chong-shan
Gong, Xing-guo
Chen, Han-min
Sheng, Xie-huang
Deng, Tong-le
Xu, Ke-di
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2007, 76 (01) : 193 - 201
[44] P2Y2 receptor activation promotes esophageal cancer cells proliferation via ERK1/2 pathway
Zaparte, Aline
Cappellari, Angelica R.
Brandao, Caroline A.
de Souza, Julia B.
Borges, Thiago J.
Kist, Luiza W.
Bogo, Mauricio R.
Zerbini, Luiz F.
Ribeiro Pinto, Luis Felipe
Glaser, Talita
Goncalves, Maria Carolina B.
Naaldijk, Yahaira
Ulrich, Henning
Morrone, Fernanda B.
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 891
[45] Anti-proliferative effects of recombinant iron superoxide dismutase on HepG2 cells via a redox-dependent PI3k/Akt pathway
Min Lu
Chong-shan Bi
Xing-guo Gong
Han-min Chen
Xie-huang Sheng
Tong-le Deng
Ke-di Xu
Applied Microbiology and Biotechnology, 2007, 76 : 193 - 201
[46] Natural pyrethrins induce autophagy of HepG2 cells through the activation of AMPK/mTOR pathway
Yang, Yun
Gao, Jufang
Zhang, Yang
Xu, Wenping
Hao, Youwu
Xu, Zhiping
Tao, Liming
ENVIRONMENTAL POLLUTION, 2018, 241 : 1091 - 1097
[47] Inhibition of MEK/ERK1/2 Signaling Affects the Fatty Acid Composition of HepG2 Human Hepatic Cell Line
Yousefi, Bahman
Darabi, Masoud
Baradaran, Behzad
Khaniani, Mahmoud Shekari
Rahbani, Mohammad
Darabi, Maryam
Fayezi, Shabnam
Mehdizadeh, Amir
Saliani, Negar
Shaaker, Maghsod
BIOIMPACTS, 2012, 2 (03) : 145 - 150
[48] MECP2 PROMOTES CELL PROLIFERATION BY ACTIVATING ERK1/2 AND INHIBITING p38 ACTIVITY IN HUMAN HEPATOCELLULAR CARCINOMA HEPG2 cells
Zhao, L. Y.
Zhang, J.
Guo, B.
Yang, J.
Han, J.
Zhao, X. G.
Wang, X. F.
Liu, L. Y.
Li, Z. F.
Song, T. S.
Huang, C.
CELLULAR AND MOLECULAR BIOLOGY, 2013, 59 : 1876 - 1881
[49] Stimulus-induced expression of the ABCG2 multidrug transporter in HepG2 hepatocarcinoma model cells involves the ERK1/2 cascade and alternative promoters
de Boussac, Hugues
Orban, Tamas I.
Varady, Gyoergy
Tihanyi, Borbala
Bacquet, Caroline
Brozik, Anna
Varadi, Andras
Sarkadi, Balazs
Aranyi, Tamas
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 426 (02) : 172 - 176
[50] Nanomolar levels of PAHs in extracts from urban air induce MAPK signaling in HepG2 cells
Jarvis, I. W. H.
Bergvall, C.
Morales, D. A.
Kummrow, F.
Umbuzeiro, G. A.
Westerholm, R.
Stenius, U.
Dreij, K.
TOXICOLOGY LETTERS, 2014, 229 (01) : 25 - 32

← 1 2 3 4 5 →