Role of Raf proteins in cardiac hypertrophy and cardiomyocyte survival

被引：55

作者：

Muslin, AJ ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Cardiovasc Res Ctr, St Louis, MO 63110 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2005年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.tcm.2005.06.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiomyocyte survival and growth are regulated by the action of extracellular ligands that activate intracellular signaling cascades. The Raf family of protein serine/threonine kinases plays a critical role in the regulation of cardiomyocyte survival and growth. The three Raf family members, Raf-1, B-Raf and A-Raf are highly homologous, and they are all expressed in the heart. Protein kinases of the Raf family phosphorylate and activate the mitogen-activated protein kinase kinases (MKKs, also known as MEKs). MKKs, in turn, are dual-specificity threonine and tyrosine kinases that phosphoiylate and activate extracellular signal-regulated kinases (ERKs). ERKs phosphorylate a variety of substrates, including nuclear transcription factors, which regulate cell physiology. Raf proteins also have antiapoptotic activity that is independent of MKK and ERK. In this review, the role of Raf family members in the regulation of cardiomyocyte survival and growth will be discussed.

引用

页码：225 / 229

页数：5

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