Neurotrophins (BDNF and NGF) in follicular fluid of women with different infertility diagnoses

被引：17
作者：
Sadeu, J. C. [1 ]
Doedee, A. M. C. M. [1 ,2 ]
Neal, M. S. [1 ,3 ]
Hughes, E. G. [1 ,3 ]
Foster, W. G. [1 ]
机构：
[1] McMaster Univ, Hlth Sci Ctr, Deptartment Obstet & Gynecol, Hamilton, ON, Canada
[2] Radboud Univ Nijmegen, NL-6525 HP Nijmegen, Netherlands
[3] ONE Fertil, Burlington, ON, Canada
来源：
REPRODUCTIVE BIOMEDICINE ONLINE | 2012年 / 24卷 / 02期
基金：
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词：
brain-derived neurotrophic factor (BDNF); follicular fluid; nerve growth factor (NGF); neurotrophins; ovary; NERVE GROWTH-FACTOR; OVARIAN-FOLLICLES; MAMMALIAN OVARY; RECEPTORS; EXPRESSION; PLASMA; TRKA; SECRETION; SURVIVAL; SYSTEM;
D O I：
10.1016/j.rbmo.2011.11.011
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are intra-ovarian signalling peptides that are important in follicle development and oocyte maturation. In the ovary, neurotrophin expression is regulated by gonadotrophins. Therefore, this study postulates that aetiology of infertility will affect follicular-fluid BDNF and NGF concentrations. Follicular fluid from the first follicle aspirated from 190 infertile women attending a university-affiliated fertility programme (McMaster University and ONE Fertility, Burlington, Ontario) was collected between February 2004 and November 2010. The relationship between follicular-fluid BDNF and NGF concentration and age, day-3 FSH and peak serum oestradiol concentrations and antral follicle count was determined. Participants were aged between 24 and 44 years (mean +/- SEM, 35.2 +/- 0.3 years) of age. The median concentrations of BDNF and NGF in the follicular fluid was 19.4 pg/ml and 344.6 ng/ml, respectively. The concentrations of BDNF and NGF were significantly related (P = 0.028) but only the BDNF concentration was significantly higher (P < 0.05) in women with unexplained infertility compared with other causes of infertility. It is concluded that, apart from unexplained infertility, the underlying cause of infertility did not affect ovarian output of BDNF and NGF in response to ovulation induction. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
引用
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页码：174 / 179
页数：6
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