Neurotrophins (BDNF and NGF) in follicular fluid of women with different infertility diagnoses

被引：18

作者：

Sadeu, J. C. ^{[1
]}

Doedee, A. M. C. M. ^{[1
,2
]}

Neal, M. S. ^{[1
,3
]}

Hughes, E. G. ^{[1
,3
]}

Foster, W. G. ^{[1
]}

机构：

[1] McMaster Univ, Hlth Sci Ctr, Deptartment Obstet & Gynecol, Hamilton, ON, Canada

[2] Radboud Univ Nijmegen, NL-6525 HP Nijmegen, Netherlands

[3] ONE Fertil, Burlington, ON, Canada

来源：

REPRODUCTIVE BIOMEDICINE ONLINE | 2012年 / 24卷 / 02期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

brain-derived neurotrophic factor (BDNF); follicular fluid; nerve growth factor (NGF); neurotrophins; ovary; NERVE GROWTH-FACTOR; OVARIAN-FOLLICLES; MAMMALIAN OVARY; RECEPTORS; EXPRESSION; PLASMA; TRKA; SECRETION; SURVIVAL; SYSTEM;

D O I：

10.1016/j.rbmo.2011.11.011

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are intra-ovarian signalling peptides that are important in follicle development and oocyte maturation. In the ovary, neurotrophin expression is regulated by gonadotrophins. Therefore, this study postulates that aetiology of infertility will affect follicular-fluid BDNF and NGF concentrations. Follicular fluid from the first follicle aspirated from 190 infertile women attending a university-affiliated fertility programme (McMaster University and ONE Fertility, Burlington, Ontario) was collected between February 2004 and November 2010. The relationship between follicular-fluid BDNF and NGF concentration and age, day-3 FSH and peak serum oestradiol concentrations and antral follicle count was determined. Participants were aged between 24 and 44 years (mean +/- SEM, 35.2 +/- 0.3 years) of age. The median concentrations of BDNF and NGF in the follicular fluid was 19.4 pg/ml and 344.6 ng/ml, respectively. The concentrations of BDNF and NGF were significantly related (P = 0.028) but only the BDNF concentration was significantly higher (P < 0.05) in women with unexplained infertility compared with other causes of infertility. It is concluded that, apart from unexplained infertility, the underlying cause of infertility did not affect ovarian output of BDNF and NGF in response to ovulation induction. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

引用

页码：174 / 179

页数：6

共 29 条

[11] Does advanced-stage endometriosis affect the gene expression of estrogen and progesterone receptors in granulosa cells? [J].

Karita, Masako ;

Yamashita, Yoshiki ;

Hayashi, Atsushi ;

Yoshida, Yoko ;

Hayashi, Mika ;

Yamamoto, Hikaru ;

Tanabe, Akiko ;

Terai, Yoshito ;

Ohmichi, Masahide .

FERTILITY AND STERILITY, 2011, 95 (03) :889-894

[12] Ovarian brain-derived neurotrophic factor (BDNF) promotes the development of oocytes into preimplantation embryos [J].

Kawamura, K ;

Kawamura, N ;

Mulders, SM ;

Gelpke, MDS ;

Hsueh, AJW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (26) :9206-9211

[13] The impact of age, weight and gender on BDNF levels in human platelets and plasma [J].

Lommatzsch, M ;

Zingler, D ;

Schuhbaeck, K ;

Schloetcke, K ;

Zingler, C ;

Schuff-Werner, P ;

Virchow, JC .

NEUROBIOLOGY OF AGING, 2005, 26 (01) :115-123

[14] Involvement of nerve growth factor in the ovulatory cascade: trkA receptor activation inhibits gap junctional communication between thecal cells [J].

Mayerhofer, A ;

Dissen, GA ;

Parrott, JA ;

Hill, DF ;

Mayerhofer, D ;

Garfield, RE ;

Costa, ME ;

Skinner, MK ;

Ojeda, SR .

ENDOCRINOLOGY, 1996, 137 (12) :5662-5670

[15] Brain derived neurotrophic factor circulating levels in patients undergoing IVF [J].

Monteleone, P. ;

Artini, P. G. ;

Simi, G. ;

Cela, V. ;

Casarosa, E. ;

Begliuomini, S. ;

Ninni, F. ;

Pluchino, N. ;

Luisi, M. ;

Genazzani, A. R. .

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2007, 24 (10) :477-480

[16] Neurotrophic and cell-cell dependent control of early follicular development [J].

Ojeda, SR ;

Romero, C ;

Tapia, V ;

Dissen, GA .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2000, 163 (1-2) :67-71

[17] TrkB receptors are required for follicular growth and oocyte survival in the mammalian ovary [J].

Paredes, A ;

Romero, CN ;

Dissen, GA ;

DeChiara, TM ;

Reichardt, L ;

Cornea, A ;

Ojeda, SR ;

Xu, BJ .

DEVELOPMENTAL BIOLOGY, 2004, 267 (02) :430-449

[18] Daily variation of brain-derived neurotrophic factor and cortisol in women with normal menstrual cycles, undergoing oral contraception and in postmenopause [J].

Pluchino, N. ;

Cubeddu, A. ;

Begliuomini, S. ;

Merlini, S. ;

Giannini, A. ;

Bucci, F. ;

Casarosa, E. ;

Luisi, M. ;

Cela, V. ;

Genazzani, A. R. .

HUMAN REPRODUCTION, 2009, 24 (09) :2303-2309

[19] Immunocytochemical evidence for the presence and location of the neurotrophin-Trk receptor family in adult human preovulatory ovarian follicles [J].

Seifer, DB ;

Feng, B ;

Shelden, RM .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2006, 194 (04) :1129-1134

[20] Ovarian brain-derived neurotrophic factor is present in follicular fluid from normally cycling women [J].

Seifer, DB ;

Lambert-Messerlian, G ;

Schneyer, AL .

FERTILITY AND STERILITY, 2003, 79 (02) :451-452

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