Neurologic and Neurobehavioral Sequelae in Children With Human Immunodeficiency Virus (HIV-1) Infection

被引:50
作者
Govender, Rajeshree [1 ]
Eley, Brian [2 ]
Walker, Kathleen [1 ]
Petersen, Revena [3 ]
Wilmshurst, Jo M. [1 ]
机构
[1] Univ Cape Town, Red Cross Childrens Hosp, Dept Pediat Neurol, Sch Child & Adolescent Hlth, ZA-7700 Cape Town, South Africa
[2] Univ Cape Town, Red Cross Childrens Hosp, Dept Infect Dis, Sch Child & Adolescent Hlth, ZA-7700 Cape Town, South Africa
[3] Univ Cape Town, Red Cross Childrens Hosp, Dept Neurodev, Sch Child & Adolescent Hlth, ZA-7700 Cape Town, South Africa
关键词
complications; HIV-1; infection; neuropathy; PEDIATRIC HIV; ANTIRETROVIRAL TREATMENT; SOUTH-AFRICA; NEURODEVELOPMENT; MANIFESTATIONS; TUBERCULOSIS; PREVALENCE; AIDS; ENCEPHALOPATHY; PATHOGENESIS;
D O I
10.1177/0883073811405203
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The range and extent of neurologic and neurobehavioral complications of human immunodeficiency virus (HIV-1) infection in children are under-described. Seventy-eight children with HIV-1 infection (32 females) were assessed for neurologic complications. Forty-six children had abnormal neurology examinations. Thirty-three children had global pyramidal tract signs, 5 had a hemiparesis, 4 had peripheral neuropathy, 18 had visual impairment, and 5 had hearing impairment. Thirty-nine of 63 children over 1 year of age had neurobehavioral problems. Of 24 children with HIV encephalopathy, 74% had severe immunosuppression and 45% were not receiving antiretroviral therapy. Twelve children had prior opportunistic central nervous system infections, and 9 had epilepsy. Diverse neurologic and neurobehavioral deficits are common in children with HIV-1 infection. Children with severe immunosuppression, who were not receiving antiretroviral therapy, were growth impaired and less than 1 year of age, were at greatest risk for developing neurologic complications.
引用
收藏
页码:1355 / 1364
页数:10
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