Periodontal, metabolic, and cardiovascular disease: Exploring the role of inflammation and mental health

被引：35

作者：

Makkar, Hina ^{[1
]}

Reynolds, Mark A. ^{[4
]}

Wadhawan, Abhishek ^{[1
,5
]}

Dagdag, Aline ^{[1
]}

Merchant, Anwar T. ^{[6
]}

Postolache, Teodor T. ^{[1
,2
,3
]}

机构：

[1] Univ Maryland, Sch Med, Dept Psychiat, Mood & Anxiety Program, Baltimore, MD 21201 USA

[2] Mil & Vet Microbiome Consortium Res & Educ MVM Co, Rocky Mt Mental Illness Res Educ & Clin Ctr MIREC, Vet Integrated Serv Network VISN 19, Denver, CO 80220 USA

[3] VA Capitol Hlth Care Network, MIRECC, Vet Integrated Serv Network VISN 5, Baltimore, MD 21201 USA

[4] Univ Maryland, Sch Dent, Dept Adv Oral Sci & Therapeut, Baltimore, MD 21201 USA

[5] St Elizabeth Hosp, Psychiat Residency Training Program, Washington, DC 20032 USA

[6] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA

来源：

PTERIDINES | 2018年 / 29卷 / 01期

关键词：

Periodontitis; metabolic syndrome; cardiovascular disease; mental illness; inflammation; C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; GINGIVAL CREVICULAR FLUID; CORONARY-HEART-DISEASE; PERIPHERAL ARTERIAL-DISEASE; GLYCATION END-PRODUCTS; ACUTE MYOCARDIAL-INFARCTION; DEPENDENT DIABETES-MELLITUS; GENOME-WIDE ASSOCIATION; ACUTE-PHASE REACTANTS;

D O I：

10.1515/pteridines-2018-0013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous evidence connects periodontal disease, a modifiable condition affecting a majority of Americans, with metabolic and cardiovascular morbidity and mortality. This review focuses on the likely mediation of these associations by immune activation and their potential interactions with mental illness. Future longitudinal, and ideally interventional studies, should focus on reciprocal interactions and cascading effects, as well as points for effective preventative and therapeutic interventions across diagnostic domains to reduce morbidity, mortality and improve quality of life.

引用

页码：124 / 163

页数：40

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