New cytotoxic sesterterpenes from the sponge Sarcotragus species

被引：45

作者：

Liu, YH

Bae, BH

Alam, N

Hong, J

Sim, CJ

Lee, CO

Im, KS

Jung, JH ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

[2] Korea Basic Sci Inst, Taejon, South Korea

[3] Hannam Univ, Dept Biol, Taejon, South Korea

[4] Korea Res Inst Chem Technol, Pharmaceut Screening Ctr, Taejon 305606, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 10期

关键词：

D O I：

10.1021/np0101494

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new (1-3, 5, and 7) and two known (4, 6) furanosesterterpene tetronic acids were isolated from the marine sponge Sarcotragus sp. by bioactivity-guided fractionation. These compounds showed cytotoxicity against a panel of five human tumor cell lines. The gross structures were established on the basis of NMR and MS analyses. The compounds showed interesting variations of geometry and absolute configuration.

引用

收藏

页码：1301 / 1304

页数：4

相关论文

共 36 条

[1] PALINURIN, A NEW LINEAR SESTERTERPENE FROM A MARINE SPONGE [J].

ALFANO, G ;

CIMINO, G ;

DESTEFANO, S .

EXPERIENTIA, 1979, 35 (09) :1136-1137

[2] OXYGENATED FURANOSESTERTERPENE TETRONIC ACIDS FROM A SPONGE OF THE GENUS IRCINIA [J].

BARROW, CJ ;

BLUNT, JW ;

MUNRO, MHG ;

PERRY, NB .

JOURNAL OF NATURAL PRODUCTS, 1988, 51 (06) :1294-1298

[3] VARIABILIN AND RELATED-COMPOUNDS FROM A SPONGE OF THE GENUS SARCOTRAGUS [J].

BARROW, CJ ;

BLUNT, JW ;

MUNRO, MHG ;

PERRY, NB .

JOURNAL OF NATURAL PRODUCTS, 1988, 51 (02) :275-281

[4] AUTOOXIDATION STUDIES ON THE MARINE SESTERTERPENE TETRONIC ACID, VARIABILIN [J].

BARROW, CJ ;

BLUNT, JW ;

MUNRO, MHG .

JOURNAL OF NATURAL PRODUCTS, 1989, 52 (02) :346-359

[5] CD OF ALPHA-BETA-UNSATURATED LACTONES [J].

BEECHAM, AF .

TETRAHEDRON, 1972, 28 (22) :5543-+

[6]

CAPON RJ, 1994, NAT PROD LETT, V4, P51

[7] Inhibition of phospholipase A(2) activities and some inflammatory responses by the marine product ircinin [J].

Cholbi, R ;

Ferrandiz, ML ;

Terencio, MC ;

DeRosa, S ;

Alcaraz, MJ ;

Paya, M .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1996, 354 (05) :677-683

[8] IRCININ-1 AND IRCININ-2 LINEAR SESTERTERPENES FROM MARINE SPONGE IRCINIA-OROS [J].

CIMINO, G ;

FATTORUSSO, E ;

MINALE, L ;

DESTEFAN.S .

TETRAHEDRON, 1972, 28 (02) :333-+

[9] The sesterterpene variabilin as a fish-predation deterrent in the western Atlantic sponge Ircinia strobilina [J].

Epifanio, RD ;

Gabriel, R ;

Martins, DL ;

Muricy, G .

JOURNAL OF CHEMICAL ECOLOGY, 1999, 25 (10) :2247-2254

[10]

FAULKNER DJ, 1973, TETRAHEDRON LETT, P3821

← 1 2 3 4 →