New Scalarane Sesterterpenoids from the Formosan Sponge Ircinia felix

被引：20

作者：

Lai, Ya-Yuan ^{[1
,2
]}

Lu, Mei-Chin ^{[1
,2
]}

Wang, Li-Hsueh ^{[1
,2
]}

Chen, Jih-Jung ^{[3
,4
]}

Fang, Lee-Shing ^{[5
]}

Wu, Yang-Chang ^{[6
,7
,8
,9
]}

Sung, Ping-Jyun ^{[1
,2
,7
,9
,10
]}

机构：

[1] Natl Dong Hwa Univ, Grad Inst Marine Biol, Pingtung 944, Taiwan

[2] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[3] Tajen Univ, Dept Pharm, Pingtung 907, Taiwan

[4] Tajen Univ, Grad Inst Pharmaceut Technol, Pingtung 907, Taiwan

[5] Cheng Shiu Univ, Dept Sport Hlth & Leisure, Kaohsiung 833, Taiwan

[6] China Med Univ, Sch Pharm, Coll Pharm, Taichung 404, Taiwan

[7] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 404, Taiwan

[8] China Med Univ Hosp, Ctr Mol Med, Taichung 404, Taiwan

[9] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[10] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

来源：

MARINE DRUGS | 2015年 / 13卷 / 07期

关键词：

TUMOR-CELL-LINES; CHEMICAL DEFENSES; MARINE SPONGES; GENUS IRCINIA; PREDATORS; ASSAY; ACID;

D O I：

10.3390/md13074296

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new scalarane sesterterpenoids, felixins A-E (1-5), were isolated from the Formosan sponge Ircinia felix. The structures of scalaranes 1-5 were elucidated on the basis of spectroscopic analysis. Cytotoxicity of scalaranes 1-5 against the proliferation of a limited panel of tumor cell lines was evaluated.

引用

页码：4296 / 4309

页数：14

共 19 条

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