Helicobacter pyloriinfection and the prevalence of hypertension in Chinese adults: The Dongfeng-Tongji cohort

Although many studies explored the association betweenhelicobacter pylori(H pylori) infection and hypertension, there is no consensus. This study is to investigate the association betweenH pyloriinfection and the prevalence of hypertension among a middle- and old-age Chinese population. A cross-sectional study including 17,100 participants from the Dongfeng-Tongji cohort study was performed. All participants underwent a(14)C-urea breath test and a routine health check-up. Logistics and linear regression with multivariable adjustment were used to quest the association betweenH pyloriinfection and hypertension. The individuals withH pyloriinfection had a higher prevalence of hypertension (57.5% vs 55.1%,P = .002), and infection rate ofH pyloriin patients with hypertension is higher than that in non-hypertensive individuals (48.8% vs 46.4%,P = .002). After adjustment for potential confounders,H pyloriinfection increased the prevalence of hypertension (odds ratio, 1.117, 95% confidence interval (CI), 1.029-1.213,P = .008). Moreover, compared with participants withoutH pyloriinfection, individuals infected had an increase of 0.905 mm Hg (95% CI, 0.025-1.785,P = .044) for diastolic blood pressure. However, there was no interaction betweenH pyloriinfection and traditional risk factors on hypertension. These findings suggested thatH pyloriinfection was positively associated with the prevalence of hypertension.