The pig: a model for human infectious diseases

被引：745

作者：

Meurens, Francois ^{[1
]}

Summerfield, Artur ^{[2
]}

Nauwynck, Hans ^{[3
]}

Saif, Linda ^{[4
]}

Gerdts, Volker ^{[5
]}

机构：

[1] INRA, Unite Rech 1282, F-37380 Tours, France

[2] Inst Virol & Immunoprophylaxis IVI, CH-3147 Mittelhausern, Switzerland

[3] Univ Ghent, Fac Vet Med, Dept Virol Parasitol & Immunol, B-9820 Merelbeke, Belgium

[4] Ohio State Univ, Ohio Agr Res & Dev Ctr, Dept Vet Prevent Med, Food Anim Hlth Res Program, Wooster, OH 44691 USA

[5] Univ Saskatchewan, Vaccine & Infect Dis Org, Saskatoon, SK S7N 5E3, Canada

来源：

TRENDS IN MICROBIOLOGY | 2012年 / 20卷 / 01期

关键词：

HUMAN ROTAVIRUS INFECTION; ANIMAL-MODELS; BORDETELLA-PERTUSSIS; MATERNAL IMMUNITY; SWINE; INFLUENZA; CELL; RESPONSES; PATHOGENESIS; REPLICATION;

D O I：

10.1016/j.tim.2011.11.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An animal model to study human infectious diseases should accurately reproduce the various aspects of disease. Domestic pigs (Sus scrofa domesticus) are closely related to humans in terms of anatomy, genetics and physiology, and represent an excellent animal model to study various microbial infectious diseases. Indeed, experiments in pigs are much more likely to be predictive of therapeutic treatments in humans than experiments in rodents. In this review, we highlight the numerous advantages of the pig model for infectious disease research and vaccine development and document a few examples of human microbial infectious diseases for which the use of pigs as animal models has contributed to the acquisition of new knowledge to improve both animal and human health.

引用

页码：50 / 57

页数：8

共 80 条

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