Chitosan/sodium alginate modificated graphene oxide-based nanocomposite as a carrier for drug delivery

被引：59
作者：
Lei, Hailin [1 ]
Xie, Meng [2 ]
Zhao, Yongwei [2 ]
Zhang, Feng [1 ]
Xu, Yuanguo [1 ]
Xie, Jimin [1 ]
机构：
[1] Jiangsu Univ, Sch Chem & Chem Engn, 301 Xuefu Rd, Zhenjiang 212013, Peoples R China
[2] Jiangsu Univ, Sch Pharm, 301 Xuefu Rd, Zhenjiang 212013, Peoples R China
来源：
CERAMICS INTERNATIONAL | 2016年 / 42卷 / 15期
基金：
中国国家自然科学基金;
关键词：
Carbon; Nanoparticles; Biomedical applications; MESOPOROUS SILICA NANOPARTICLES; CONTROLLED-RELEASE; IN-VITRO; FUNCTIONALIZED GRAPHENE; HYBRID NANOPARTICLES; ORAL BIOAVAILABILITY; TARGETED DELIVERY; CARBON NANOTUBES; MICROSPHERES; DOXORUBICIN;
D O I：
10.1016/j.ceramint.2016.08.108
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The anti-cancer drug loaded nanocarrier of functionalized graphene oxide (GO) with chitosan (CS) and sodium alginate (SA) was prepared successfully through electrostatic self-assembly process. The anticancer drug doxorubicin hydrochloride (DOX) was incorporated into the nanocomposites and the resulted DOX-loaded products displayed significant pH-dependent drug release behaviors. The modification of GO with CS and SA increased the solubility of both GO and DOX loaded GO nanocomposites as well as limited the undesired non-specific adsorption of protein in physiological conditions. Additionally, the GO-CS/SA nanocomposites could be internalized by MCF-7 cancer cells and the DOX loaded compositions displayed a remarkable cytotoxicity to the tumor cells. Therefore, the GO-CS/SA nanoparticles proved to be potential materials for delivery of anti-tumor drugs. (C) 2016 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
引用
收藏
页码：17798 / 17805
页数：8
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