In Vivo UTE-MRI Reveals Positive Effects of Raloxifene on Skeletal-Bound Water in Skeletally Mature Beagle Dogs

被引：23

作者：

Allen, Matthew R. ^{[1
]}

Territo, Paul R. ^{[2
]}

Lin, Chen ^{[2
]}

Persohn, Scott ^{[2
]}

Jiang, Lei ^{[2
]}

Riley, Amanda A. ^{[2
]}

McCarthy, Brian P. ^{[2
]}

Newman, Christopher L. ^{[1
]}

Burr, David B. ^{[1
]}

Hutchins, Gary D. ^{[2
]}

机构：

[1] Indiana Univ Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA

[2] Indiana Univ Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2015年 / 30卷 / 08期

关键词：

HYDRATION; CORTICAL BONE; SERMS; NONINVASIVE IMAGING; VERTEBRAL FRACTURE RISK; CORTICAL BONE; MECHANICAL-PROPERTIES; TURNOVER;

D O I：

10.1002/jbmr.2470

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Raloxifene positively affects mechanical properties of the bone matrix in part through modification of skeletal-bound water. The goal of this study was to determine if raloxifene-induced alterations in skeletal hydration could be measured in vivo using ultra-short echotime magnetic resonance imaging (UTE-MRI). Twelve skeletally mature female beagle dogs (n=6/group) were treated for 6 months with oral doses of saline vehicle (VEH, 1mL/kg/d) or raloxifene (RAL, 0.5mg/kg/d). After 6 months of treatment, all animals underwent in vivo UTE-MRI of the proximal tibial cortical bone. UTE-MRI signal intensity versus echotime curves were analyzed by fitting a double exponential to determine the short and long relaxation times of water with the bone (dependent estimations of bound and free water, respectively). Raloxifene-treated animals had significantly higher bound water (+14%; p=0.05) and lower free water (-20%) compared with vehicle-treated animals. These data provide the first evidence that drug-induced changes in skeletal hydration can be noninvasively assessed using UTE-MRI. (c) 2015 American Society for Bone and Mineral Research. (c) 2015 American Society for Bone and Mineral Research.

引用

页码：1441 / 1444

页数：4

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