Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank

被引：915

作者：

Alfaro-Almagro, Fidel ^{[1
]}

Jenkinson, Mark ^{[1
]}

Bangerter, Neal K. ^{[2
]}

Andersson, Jesper L. R. ^{[1
]}

Griffanti, Ludovica ^{[1
]}

Douaud, Gwenaelle ^{[1
]}

Sotiropoulos, Stamatios N. ^{[1
,3
]}

Jbabdi, Saad ^{[1
]}

Hernandez-Fernandez, Moises ^{[1
]}

Vallee, Emmanuel ^{[1
]}

Vidaurre, Diego ^{[4
]}

Webster, Matthew ^{[1
]}

McCarthy, Paul ^{[1
]}

Rorden, Christopher ^{[5
,6
]}

Daducci, Alessandro ^{[7
,8
]}

Alexander, Daniel C. ^{[9
]}

Zhang, Hui ^{[9
]}

Dragonu, Iulius ^{[10
]}

Matthews, Paul M. ^{[11
,12
]}

Miller, Karla L. ^{[1
]}

Smith, Stephen M. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Clin Neurosci, Wellcome Ctr Integrat Neuroimaging, FMRIB, Oxford, England

[2] Brigham Young Univ, Elect & Comp Engn, Provo, UT 84602 USA

[3] Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Med, Nottingham, England

[4] Univ Oxford, Dept Psychiat, Oxford Ctr Human Brain Act, Wellcome Ctr Integrat Neuroimaging, Oxford, England

[5] Univ South Carolina, Dept Psychol, Columbia, SC 29208 USA

[6] Univ South Carolina, McCausland Ctr Brain Imaging, Columbia, SC 29208 USA

[7] Univ Verona, Comp Sci Dept, Verona, Italy

[8] Univ Hosp Ctr, Radiol Dept, Zurich, Switzerland

[9] UCL, Dept Comp Sci, Ctr Med Image Comp, London, England

[10] Siemens Healthcare, Surrey, England

[11] Imperial Coll, Div Brain Sci, London, England

[12] UK Dementia Res Inst, London, England

来源：

NEUROIMAGE | 2018年 / 166卷

基金：

英国医学研究理事会; 英国惠康基金; 英国工程与自然科学研究理事会;

关键词：

Epidemiological studies; Image analysis pipeline; Multi-modal data integration; Quality control; Big data imaging; Machine learning; INDEPENDENT COMPONENT ANALYSIS; ECHO-PLANAR IMAGES; WHITE-MATTER; DIFFUSION TENSOR; SPATIAL STATISTICS; FMRI; ROBUST; OPTIMIZATION; REPRODUCIBILITY; CLASSIFICATION;

D O I：

10.1016/j.neuroimage.2017.10.034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

UK Biobank is a large-scale prospective epidemiological study with all data accessible to researchers worldwide. It is currently in the process of bringing back 100,000 of the original participants for brain, heart and body MRI, carotid ultrasound and low-dose bone/fat x-ray. The brain imaging component covers 6 modalities (T1, T2 FLAIR, susceptibility weighted MRI, Resting fMRI, Task fMRI and Diffusion MRI). Raw and processed data from the first 10,000 imaged subjects has recently been released for general research access. To help convert this data into useful summary information we have developed an automated processing and QC (Quality Control) pipeline that is available for use by other researchers. In this paper we describe the pipeline in detail, following a brief overview of UK Biobank brain imaging and the acquisition protocol. We also describe several quantitative investigations carried out as part of the development of both the imaging protocol and the processing pipeline.

引用

页码：400 / 424

页数：25

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