WHO 2016 Classification of gliomas

被引:606
作者
Wesseling, P. [1 ,2 ]
Capper, D. [3 ,4 ,5 ,6 ]
机构
[1] Vrije Univ Amsterdam, Med Ctr, Brain Tumor Ctr Amsterdam, Dept Pathol, Amsterdam, Netherlands
[2] Univ Med Ctr Utrecht, Princess Maxima Ctr Pediat Oncol, Dept Pathol, Utrecht, Netherlands
[3] Heidelberg Univ, Inst Pathol, Dept Neuropathol, Heidelberg, Germany
[4] German Canc Consortium DKTK, German Canc Res Ctr DKFZ, Clin Cooperat Unit Neuropathol, Heidelberg, Germany
[5] Charite, Freie Univ Berlin, Humboldt Univ Berlin, Berlin, Germany
[6] Berlin Inst Hlth, Dept Neuropathol, Berlin, Germany
关键词
1p/19q codeletion; astrocytoma; classification; glioblastoma; glioma; IDH mutation; molecular diagnostics; oligodendroglioma; World Health Organization; CODON; 132; MUTATION; MOLECULAR CLASSIFICATION; GENOMIC ANALYSIS; K27M MUTATIONS; GRADE II; OLIGODENDROGLIOMA; DIFFUSE; IDH; TUMORS; GLIOBLASTOMA;
D O I
10.1111/nan.12432
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Gliomas are the most frequent intrinsic tumours of the central nervous system and encompass two principle subgroups: diffuse gliomas and gliomas showing a more circumscribed growth pattern ('nondiffuse gliomas'). In the revised fourth edition of the WHO Classification of CNS tumours published in 2016, classification of especially diffuse gliomas has fundamentally changed: for the first time, a large subset of these tumours is now defined based on presence/absence of IDH mutation and 1p/19q codeletion. Following this approach, the diagnosis of (anaplastic) oligoastrocytoma can be expected to largely disappear. Furthermore, in the WHO 2016 Classification gliomatosis cerebri is not an entity anymore but is now considered as a growth pattern. The most important changes in the very diverse group of 'nondiffuse' gliomas and neuronal-glial tumours are the introduction of anaplastic pleomorphic xanthoastrocytoma, of diffuse leptomeningeal glioneuronal tumour and of RELA fusion-positive ependymoma as entities. In the last part of this review, after very briefly touching upon classification of neuronal, choroid plexus and pineal region tumours, some practical implications and challenges associated with the WHO 2016 Classification of gliomas are discussed.
引用
收藏
页码:139 / 150
页数:12
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