Experimentally Induced Toxicity of Ochratoxin A and Endosulfan in Male Wistar Rats: A Hormonal Disorder

被引：0

作者：

Kumar, Shashi Nandar ^{[2
]}

Telang, Avinash Gopal ^{[3
]}

Singh, Karan Pal ^{[3
]}

Jain, Arun Kumar ^{[2
]}

Afroz, Masarrat ^{[4
]}

Patil, Rajendra Damu ^{[1
]}

机构：

[1] CSK Himachal Pradesh Agr Univ, Dr GC Negi Coll Vet & Anim Sci, Dept Vet Pathol, Palampur 176062, Himachal Prades, India

[2] Inst Pathol, New Delhi 110029, India

[3] Indian Vet Res Inst, Ctr Anim Dis Res & Diag, Izatnagar 243122, Uttar Pradesh, India

[4] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India

来源：

JOURNAL OF ANIMAL AND VETERINARY ADVANCES | 2011年 / 10卷 / 13期

关键词：

Ochratoxin A; endosulfan; male rats; hormone; radioimmuno assay; India; TROUT ONCORHYNCHUS-MYKISS; NEONATAL-HYPOTHYROIDISM; CORTISOL SECRETION; IN-VITRO; CELLS; INTOXICATION; INSECTICIDE; ANIMALS; PLASMA;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Dietary exposures to food contaminants such as mycotoxin (s) or pesticide (s) are most significant due to their adverse effect on the production and reproduction in animals and human population. The present investigation was conducted to evaluate the adverse effects of Ochratoxin A (OTA) and endosulfan on the male hormonal status. OTA (4 mg kg(-1) feed) and endosulfan (5 mg kg(-1) body weight) were administered orally alone and in combination for 30 days caused significant alterations on the serum levels of various body hormones such as thyroid hormones (triiodothyronine and thyroxin), testosterone, prolactin, insulin and cortisol of adult male Wistar rats. Radioimmuno assay revealed significantly higher serum levels of Thyroxin (T-4) and prolactin and the significantly lower serum levels of Triiodothyronine (T-3), testosterone, insulin and cortisol in all the treated groups in comparison to control. Moreover, the hormonal changes were maximum in the combination group. In conclusion, the simultaneous exposure of OTA and endosulfan caused more pronounced hormonal alterations possibly may due to their additive interaction in adult male Wistar rats.

引用

页码：1750 / 1755

页数：6

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