Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review)

被引：20

作者：

Steinmann, Sara ^{[1
]}

Scheibe, Kristina ^{[3
]}

Erlenbach-Wuensch, Katharina ^{[2
]}

Neufert, Clemens ^{[3
]}

Schneider-Stock, Regine ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Expt Tumorpathol, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Inst Pathol, D-91054 Erlangen, Germany

[3] Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Med 1, D-91052 Erlangen, Germany

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2015年 / 47卷 / 01期

关键词：

inflammatory bowel disease; death-associated protein kinase; colorectal carcinogenesis; INTESTINAL EPITHELIAL-CELLS; COLORECTAL-CANCER CELLS; TNF-INDUCED APOPTOSIS; KAPPA-B ACTIVATION; DAP-KINASE; ULCERATIVE-COLITIS; CROHNS-DISEASE; SERINE/THREONINE KINASE; MAINTENANCE THERAPY; OXIDATIVE STRESS;

D O I：

10.3892/ijo.2015.2998

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cytoskeleton-associated serine/threonine kinase death-associated protein kinase (DAPK) has been described as a cancer gene chameleon with functional antagonistic duality in a cell type and context specific manner. The broad range of interaction partners and substrates link DAPK to inflammatory processes especially in the gut. Herein we summarize our knowledge on the role of DAPK in different cell types that play a role under inflammatory conditions in the gut. Besides some promising experimental data suggesting DAPK as an interesting drug target in inflammatory bowel disease there are many open questions regarding direct evidence for a role of DAPK in intestinal inflammation.

引用

页码：5 / 15

页数：11

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