Studies on preparation and swelling properties of the N-isopropylacrylamide/chitosan semi-IPN and IPN hydrogels

被引：149

作者：

Lee, WF ^{[1
]}

Chen, YJ ^{[1
]}

机构：

[1] Tatung Univ, Dept Chem Engn, Taipei 10451, Taiwan

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2001年 / 82卷 / 10期

关键词：

hydrogel; interpenetrating network; N-isopropylacrylamide; chitosan;

D O I：

10.1002/app.2099

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Semi-interpenetrating network (semi-IPN) polymer gels and interpenetrating network (IPN) polymer gels with thermosensitivity were prepared by introducing a biodegradable polymer, chitosan, into the N-isopropyacrylamide (PNIPAAm) gel system. The swelling behavior, temperature sensitivity, pH sensitivity, gel strength, and drug-release behavior of PNIPAAm/chitosan semi-IPN and IPN hydrogels were investigated. The results indicated that the NIPAAm/chitosan semi-IPN and IPN hydrogels exhibited pH and temperature-sensitivity behavior and could slow drug release and diffusion from the gels. From the stress-strain curves of the hydrogels, the compression moduli of IPN gels containing crosslinked chitosan were higher than those of semi-IPN gels. This is because IPN gels have a more compact structure. The morphology of PNIPAAm/chitosan hydrogels was also investigated. (C) 2001 John Wiley & Sons, Inc.

引用

页码：2487 / 2496

页数：10

共 57 条

[1] Morphology and thermal properties of pseudo interpenetrating polymer networks based on natural rubber (Manihot glaziovii) and poly(methyl methacrylate) [J].