Synthesis of novel 2-(alkyl/arylamino)-2-oxo-1-(quinolin-4-yl)ethyl cinnamates through three-component reaction between an isocyanide, quinoline-4-carbaldehyde and cinnamic acid derivatives

被引：2

作者：

Taran, Jafar ^{[1
]}

Ramazani, Ali ^{[1
,2
]}

机构：

[1] Univ Zanjan, Fac Sci, Dept Chem, Zanjan 4537138791, Iran

[2] Univ Zanjan, Res Inst Modern Biol Tech RIMBT, Dept Biotechnol, Zanjan 4537138791, Iran

来源：

EURASIAN CHEMICAL COMMUNICATIONS | 2022年 / 4卷 / 04期

关键词：

Multicomponent reactions (MCRs); Passerini reactions; quinoline-4-carbaldehyde; isocyanide; cinnamic acid derivatives; STABILIZED PHOSPHORUS YLIDES; GEL CATALYZED CONVERSION; ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; SILICA-GEL; PARALLEL SYNTHESIS; DRUG DISCOVERY; (N-ISOCYANIMINO)TRIPHENYLPHOSPHORANE; INDANE-1,2,3-TRIONE; CONDENSATION;

D O I：

10.22034/ecc.2022.316470.1269

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Passerini reactions of an isocyanide, quinoline-4-carbaldehyde, and cinnamic acid derivatives in water proceed at room temperature giving 2-(alkyl/aryl amino)-2-oxo-1-(quinolin-4-yl)ethyl cinnamate derivatives in quantitative yield. The reactions are one-pot, and the products did not require any purification. This procedure offers significant advantages such as operational simplicity, mild reaction conditions, enhanced rates, cleaner reaction profiles, ease of isolation of products, and H2O as a medium, making it a valuable protocol for synthesizing these compounds.

引用

页码：319 / 329

页数：11

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