Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release

被引：68

作者：

Lensen, Dennis ^{[1
,2
]}

Gelderblom, Erik C. ^{[3
]}

Vriezema, Dennis M. ^{[2
]}

Marmottant, Philippe ^{[4
]}

Verdonschot, Nico ^{[5
,6
]}

Versluis, Michel ^{[3
]}

de Jong, Nico ^{[3
,7
,8
]}

van Hest, Jan C. M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 ED Nijmegen, Netherlands

[2] Encapson BV, Nijmegen, Netherlands

[3] Univ Twente, MIRA Inst Biomed Technol & Tech Med, Phys Fluids Grp, NL-7500 AE Enschede, Netherlands

[4] Univ Grenoble 1, CNRS, Lab Interdisciplinaire Phys, UMR 5588, Grenoble, France

[5] Radboud Univ Nijmegen, Med Ctr, Orthopaed Res Lab, NL-6525 ED Nijmegen, Netherlands

[6] Univ Twente, Dept Biomech Engn, NL-7500 AE Enschede, Netherlands

[7] Erasmus MC, Dept Expt Echocardiog, Rotterdam, Netherlands

[8] Interuniv Cardiol Inst Netherlands, Utrecht, Netherlands

来源：

SOFT MATTER | 2011年 / 7卷 / 11期

关键词：

MICROBUBBLE CONTRAST AGENTS; DIAGNOSTIC ULTRASOUND; OPTICAL OBSERVATION; DESTRUCTION; BUBBLES; DELIVERY; MODEL;

D O I：

10.1039/c1sm05324h

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A series of hollow biodegradable polymeric microcapsules were prepared, of which their susceptibility to ultrasound was used for triggered release. High speed imaging of the ultrasound experiments showed a strong correlation between the acoustic pressure needed to activate these microcapsules and their shell thickness to diameter ratio. Based on this information a selective triggering of capsules with two different shell thickness to diameter ratios was successfully performed. The capsules were mixed in a single system and were activated independently from each other by a differentiation in acoustic pressure levels. This application is of great interest in the field of drug delivery, since this system allows for localized multiple drug releases in a selective fashion.

引用

页码：5417 / 5422

页数：6

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