Safety and antibody response to inactivated COVID-19 vaccine in patients with chronic hepatitis B virus infection

被引：41

作者：

He, Taiyu ^{[1
]}

Zhou, Yingzhi ^{[1
]}

Xu, Pan ^{[1
]}

Ling, Ning ^{[1
]}

Chen, Min ^{[1
]}

Huang, Tianquan ^{[1
]}

Zhang, Biqiong ^{[1
]}

Yang, Ziqiao ^{[1
]}

Ao, Ling ^{[1
]}

Li, Hu ^{[1
]}

Chen, Zhiwei ^{[1
]}

Zhang, Dazhi ^{[1
]}

Shi, Xiaofeng ^{[1
]}

Lei, Yu ^{[1
]}

Wang, Zhiyi ^{[1
]}

Zeng, Weiqun ^{[1
]}

Hu, Peng ^{[1
]}

Lan, Yinghua ^{[1
]}

Zhou, Zhi ^{[1
]}

Kang, Juan ^{[1
]}

Huang, Ying ^{[1
]}

Shi, Tongdong ^{[1
]}

Pan, Qingbo ^{[1
]}

Zhu, Qian ^{[1
]}

Ran, Xiping ^{[1
]}

Zhang, Yingzhi ^{[1
]}

Song, Rui ^{[1
]}

Xiang, Dejuan ^{[1
]}

Xiao, Shuang ^{[1
]}

Zhang, Gaoli ^{[1
]}

Shen, Wei ^{[1
]}

Peng, Mingli ^{[1
]}

Cai, Dachuan ^{[1
]}

Ren, Hong ^{[1
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 2, Dept Infect Dis, Inst Viral Hepatitis,Minist Educ,Key Lab Mol Biol, Chongqing, Peoples R China

来源：

LIVER INTERNATIONAL | 2022年 / 42卷 / 06期

基金：

中国国家自然科学基金;

关键词：

antibody response; CHB; cirrhosis; COVID-19; vaccine; safety; CELLS;

D O I：

10.1111/liv.15173

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background and Aims The safety and antibody responses of coronavirus disease 2019 (COVID-19) vaccination in patients with chronic hepatitis B (CHB) virus infection is still unclear, and exploration in safety and antibody responses of COVID-19 vaccination in CHB patients is significant in clinical practice. Methods 362 adult CHB patients and 87 healthy controls at an interval of at least 21 days after a full-course vaccination (21-105 days) were enrolled. Adverse events (AEs) were collected by questionnaire. The antibody profiles at 1, 2 and 3 months were elucidated by determination of anti-spike IgG, anti-receptor-binding domain (RBD) IgG, and RBD-angiotensin-converting enzyme 2 blocking antibody. SARS-CoV-2 specific B cells were also analysed. Results All AEs were mild and self-limiting, and the incidence was similar between CHB patients and controls. Seropositivity rates of three antibodies were similar between CHB patients and healthy controls at 1, 2 and 3 months, but CHB patients had lower titers of three antibodies at 1 month. Compared to healthy controls, HBeAg-positive CHB patients had higher titers of three antibodies at 3 months (all P < .05) and a slower decline in antibody titers. Frequency of RBD-specific B cells was positively correlated with titers of anti-RBD IgG (OR = 1.067, P = .004), while liver cirrhosis, antiviral treatment, levels of HBV DNA, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and total bilirubin (TB) were not correlated with titers of anti-RBD IgG. Conclusions Inactivated COVID-19 vaccines were well tolerated, and induced effective antibody response against SARS-CoV-2 in CHB patients.

引用

页码：1287 / 1296

页数：10

共 25 条

[1] Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset [J].