Stereodivergent Ruthenium-Catalyzed Transfer Semihydrogenation of Diaryl Alkynes

被引：79
作者：
Li, Jie [1 ]
Hua, Ruimao [1 ]
机构：
[1] Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Minist Educ, Beijing 100084, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 30期
基金：
中国国家自然科学基金;
关键词：
alkynes; alkenes; hydrogenation; ruthenium; stereoselectivity; TRANSFER HYDROGENATION; STRUCTURAL MODIFICATIONS; REDUCTIVE AMINATION; CANCER-CELLS; IN-VIVO; RESVERATROL; KETONES; MECHANISM; ALKENES; N; N-DIMETHYLFORMAMIDE;
D O I：
10.1002/chem.201003662
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[Ru-3(CO)(12)]-catalyzed transfer semihydrogenation of various functionalized diaryl alkynes with N,N-dimethylformamide (DMF) and water as hydrogen source affords cis- and trans-stilbenes. The stereodivergent approach can be switched by the use of acetic (HOAc) or trifluoroacetic (TFA) acid as additives. The catalytic processes can be applied to the synthesis of analogues of natural products such as cis-combretastatin A-4 and trans-resveratrol.
引用
收藏
页码：8462 / 8465
页数：4
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