Equilibrium solubility, preferential solvation and apparent specific volume of sucrose in some {cosolvent (1) + water (2)} mixtures at 298.2 K

被引:11
作者
Tinjaca, Dario A. [1 ]
Munoz, Maria M. [1 ]
Jouyban, Abolghasem [2 ,3 ,4 ]
Martinez, Fleming [1 ]
Acree, William E. [5 ]
机构
[1] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fisicoquim, Bogota, Colombia
[2] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran
[3] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran
[4] Tabriz Univ Med Sci, Kimia Idea Pardaz Azarbayjan KIPA Sci Based Co, Tabriz, Iran
[5] Univ North Texas, Dept Chem, Denton, TX 76203 USA
关键词
Sucrose; cosolvents; solubility; cosolvency; apparent specific volume; Jouyban-Acree model; preferential solvation; PLUS WATER MIXTURES; AQUEOUS COSOLVENT MIXTURES; PARTIAL MOLAR VOLUMES; PHARMACEUTICAL SALTS; BINARY; TEMPERATURES; SATURATION; METHANOL; ETHANOL; ACETAMINOPHEN;
D O I
10.1080/00319104.2018.1439028
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Sucrose is the most widely used sweetener in food and pharmaceuticals. Solubility data of this excipient in aqueous cosolvent mixtures is not abundant. Thus, the main objective of this research was to determine and correlate the equilibrium solubility of sucrose in some {cosolvent (1) + water (2)} mixtures at 298.2 K. Cosolvents were ethanol, propylene glycol and glycerol. Shaken flask method was used to determine isothermal solubility. Concentration measurements were performed by means of density determinations. Solubility of sucrose decreases non-linearly with the addition of cosolvent to water. By means of the inverse Kirkwood-Buff method it is shown that sucrose is preferentially solvated by cosolvent in water-rich mixtures but preferentially solvated by water in cosolvent-rich mixtures. Jouyban-Acree model correlates solubility values with the mixtures composition for all cosolvent systems. Moreover, apparent specific volume of sucrose was also calculated from density and compositions.
引用
收藏
页码:259 / 273
页数:15
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