MEK Is a Therapeutic and Chemopreventative Target in Squamous Cell Carcinoma

被引：14

作者：

Adelmann, Charles H. ^{[1
]}

Truong, Kimberly A. ^{[1
]}

Liang, Roger J. ^{[1
]}

Bansal, Varun ^{[1
]}

Gandee, Leah ^{[1
]}

Saporito, Rachael C. ^{[1
]}

Lee, Woojin ^{[1
]}

Du, Lili ^{[1
]}

Nicholas, Courtney ^{[1
]}

Napoli, Marco ^{[2
]}

Mino, Barbara ^{[1
]}

South, Andrew P. ^{[4
]}

Proby, Charlotte M. ^{[5
]}

Leigh, Irene M. ^{[6
]}

Coarfa, Cristian ^{[7
]}

Flores, Elsa R. ^{[2
]}

Tsai, Kenneth Y. ^{[1
,3
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Dermatol, Houston, TX 77030 USA

[4] Jefferson Univ, Dept Dermatol, Philadelphia, PA 19107 USA

[5] Univ Dundee, Ninewells Hosp & Med Sch, Ctr Mol Med, Dundee, Scotland

[6] Univ Dundee, Ninewells Hosp & Med Sch, Jacqui Wood Canc Ctr, Dundee, Scotland

[7] Baylor Coll Med, Dept Mol Biol, Houston, TX 77030 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2016年 / 136卷 / 09期

关键词：

BRAF INHIBITORS; RAS MUTATIONS; SKIN;

D O I：

10.1016/j.jid.2016.05.110

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

[No abstract available]

引用

页码：1920 / 1924

页数：6

共 15 条

[1] NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia [J].

Dajee, M ;

Lazarov, M ;

Zhang, JY ;

Cai, T ;

Green, CL ;

Russell, AJ ;

Marinkovich, MP ;

Tao, SY ;

Lin, Q ;

Kubo, Y ;

Khavari, PA .

NATURE, 2003, 421 (6923) :639-643

[2] Functional Protein Pathway Activation Mapping of the Progression of Normal Skin to Squamous Cell Carcinoma [J].

Einspahr, Janine G. ;

Calvert, Valerie ;

Alberts, David S. ;

Curiel-Lewandrowski, Clara ;

Warneke, James ;

Krouse, Robert ;

Stratton, Steven P. ;

Liotta, Lance ;

Longo, Caterina ;

Pellicani, Giovanni ;

Prasad, Anil ;

Sagerman, Paul ;

Bermudez, Yira ;

Deng, Jianghong ;

Bowden, G. Timothy ;

Petricoin, Emanuel F., III .

CANCER PREVENTION RESEARCH, 2012, 5 (03) :403-413

[3] Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma [J].

Flaherty, Keith T. ;

Robert, Caroline ;

Hersey, Peter ;

Nathan, Paul ;

Garbe, Claus ;

Milhem, Mohammed ;

Demidov, Lev V. ;

Hassel, Jessica C. ;

Rutkowski, Piotr ;

Mohr, Peter ;

Dummer, Reinhard ;

Trefzer, Uwe ;

Larkin, James M. G. ;

Utikal, Jochen ;

Dreno, Brigitte ;

Nyakas, Marta ;

Middleton, Mark R. ;

Becker, Juergen C. ;

Casey, Michelle ;

Sherman, Laurie J. ;

Wu, Frank S. ;

Ouellet, Daniele ;

Martin, Anne-Marie ;

Patel, Kiran ;

Schadendorf, Dirk .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (02) :107-114

[4] Cutaneous squamous cell carcinoma: Estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012 [J].

Karia, Pritesh S. ;

Han, Jiali ;

Schmults, Chrysalyne D. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2013, 68 (06) :957-966

[5] Genomic Analysis of Metastatic Cutaneous Squamous Cell Carcinoma [J].

Li, Yvonne Y. ;

Hanna, Glenn J. ;

Laga, Alvaro C. ;

Haddad, Robert I. ;

Lorch, Jochen H. ;

Hammerman, Peter S. .

CLINICAL CANCER RESEARCH, 2015, 21 (06) :1447-1456

[6] Paradoxical oncogenesis: are all BRAF inhibitors equal? [J].

Menzies, Alexander M. ;

Kefford, Richard F. ;

Long, Georgina V. .

PIGMENT CELL & MELANOMA RESEARCH, 2013, 26 (05) :611-615

[7] Cellular senescence: from physiology to pathology [J].

Munoz-Espin, Daniel ;

Serrano, Manuel .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (07) :482-+

[8] RAS Mutations Are Associated With the Development of Cutaneous Squamous Cell Tumors in Patients Treated With RAF Inhibitors [J].

Oberholzer, Patrick A. ;

Kee, Damien ;

Dziunycz, Piotr ;

Sucker, Antje ;

Kamsukom, Nyam ;

Jones, Robert ;

Roden, Christine ;

Chalk, Clinton J. ;

Ardlie, Kristin ;

Palescandolo, Emanuele ;

Piris, Adriano ;

MacConaill, Laura E. ;

Robert, Caroline ;

Hofbauer, Guenther F. L. ;

McArthur, Grant A. ;

Schadendorf, Dirk ;

Garraway, Levi A. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (03) :316-321

[9] Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma [J].

Pickering, Curtis R. ;

Zhou, Jane H. ;

Lee, J. Jack ;

Drummond, Jennifer A. ;

Peng, S. Andrew ;

Saade, Rami E. ;

Tsai, Kenneth Y. ;

Curry, Jonathan L. ;

Tetzlaff, Michael T. ;

Lai, Stephen Y. ;

Yu, Jun ;

Muzny, Donna M. ;

Doddapaneni, Harshavardhan ;

Shinbrot, Eve ;

Covington, Kyle R. ;

Zhang, Jianhua ;

Seth, Sahil ;

Caulin, Carlos ;

Clayman, Gary L. ;

El-Naggar, Adel K. ;

Gibbs, Richard A. ;

Weber, Randal S. ;

Myers, Jeffrey N. ;

Wheeler, David A. ;

Frederick, Mitchell J. .

CLINICAL CANCER RESEARCH, 2014, 20 (24) :6582-6592

[10] NOTCH1 Mutations Occur Early during Cutaneous Squamous Cell Carcinogenesis [J].

South, Andrew P. ;

Purdie, Karin J. ;

Watt, Stephen A. ;

Haldenby, Sam ;

den Breems, Nicoline Y. ;

Dimon, Michelle ;

Arron, Sarah T. ;

Kluk, Michael J. ;

Aster, Jon C. ;

McHugh, Angela ;

Xue, Dylan J. ;

Dayal, Jasbani H. S. ;

Robinson, Kim S. ;

Rizvi, S. M. Hasan ;

Proby, Charlotte M. ;

Harwood, Catherine A. ;

Leigh, Irene M. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2014, 134 (10) :2630-2638

← 1 2 →