Importance of Ring Puckering versus Interstrand Hydrogen Bonds for the Conformational Stability of Collagen

被引：78
作者：
Erdmann, Roman S. [1 ]
Wennemers, Helma [1 ]
机构：
[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 30期
关键词：
cis/trans amide bonds; collagen; PPII helix; proline; protein engineering; TRIPLE-HELIX; MODEL PEPTIDES; CRYSTAL-STRUCTURE; 4-HYDROXYPROLINE; STABILIZATION; HYDROXYLATION; ASSOCIATION; RESOLUTION;
D O I：
10.1002/anie.201008118
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Mismatch is fine: Proline derivatives with a ring pucker mismatching that of natural collagen but with favorable torsional angles along the peptide chain are readily tolerated within the collagen triple helix (see picture). In contrast, a competition between intramolecular and interstrand H bonds destabilizes the collagen triple helix. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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收藏
页码：6835 / 6838
页数：4
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