Identification of a Novel Benzimidazole That Inhibits Bacterial Biofilm Formation in a Broad-Spectrum Manner

被引:81
|
作者
Sambanthamoorthy, Karthik [1 ,2 ]
Gokhale, Ankush A. [3 ]
Lao, Weiwei [4 ]
Parashar, Vijay [5 ]
Neiditch, Matthew B. [5 ]
Semmelhack, Martin F. [4 ]
Lee, Ilsoon [3 ]
Waters, Christopher M. [1 ,2 ]
机构
[1] Michigan State Univ, Dept Microbiol, E Lansing, MI 48824 USA
[2] Michigan State Univ, Dept Mol Genet, E Lansing, MI 48824 USA
[3] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA
[4] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA
[5] UMDNJ New Jersey Med Sch, Dept Microbiol & Mol Genet, Newark, NJ 07103 USA
关键词
STAPHYLOCOCCUS-AUREUS; EPIDERMIDIS; PATHOGENS; VIRULENCE; SURVIVAL; RELEASE; ACID;
D O I
10.1128/AAC.00583-11
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Bacterial biofilm formation causes significant industrial economic loss and high morbidity and mortality in medical settings. Biofilms are defined as multicellular communities of bacteria encased in a matrix of protective extracellular polymers. Because biofilms have a high tolerance for treatment with antimicrobials, protect bacteria from immune defense, and resist clearance with standard sanitation protocols, it is critical to develop new approaches to prevent biofilm formation. Here, a novel benzimidazole molecule, named antibiofilm compound 1 (ABC-1), identified in a small-molecule screen, was found to prevent bacterial biofilm formation in multiple Gram-negative and Gram-positive bacterial pathogens, including Pseudomonas aeruginosa and Staphylococcus aureus, on a variety of different surface types. Importantly, ABC-1 itself does not inhibit the growth of bacteria, and it is effective at nanomolar concentrations. Also, coating a polystyrene surface with ABC-1 reduces biofilm formation. These data suggest ABC-1 is a new chemical scaffold for the development of antibiofilm compounds.
引用
收藏
页码:4369 / 4378
页数:10
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