Synthesis of Novel N4-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents

被引：5

作者：

Amblard, Franck ^{[1
]}

LeCher, Julia C.

De, Ramyani

Goh, Shu Ling

Li, Chengwei

Kasthuri, Mahesh

Biteau, Nicolas

Zhou, Longhu

Tber, Zahira

Downs-Bowen, Jessica

Zandi, Keivan

Schinazi, Raymond F. ^{[1
]}

机构：

[1] Emory Univ, Ctr ViroSci Cure, Dept Pediat, Lab Biochem Pharmacol,Sch Med, 1760 Haygood Dr, Atlanta, GA 30322 USA

来源：

PHARMACEUTICALS | 2022年 / 15卷 / 09期

关键词：

nucleoside; antiviral agents; COVID-19; SARS-COV-2;

D O I：

10.3390/ph15091144

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Molnupiravir, an ester prodrug form of N-4-hydroxycytidine (NHC), was recently emergency-use approved for the treatment of early SARS-CoV-2 infections. Herein, we report the synthesis and evaluation of a series of novel NHC analogs.

引用

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