The Left Half of the XMRV Retrovirus Is Present in an Endogenous Retrovirus of NIH/3T3 Swiss Mouse Cells

被引：21

作者：

Mendoza, Ramon ^{[1
]}

Vaughan, Andrew E. ^{[1
]}

Miller, A. Dusty ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA

来源：

JOURNAL OF VIROLOGY | 2011年 / 85卷 / 17期

关键词：

VIRUS; SEQUENCES; BLOOD;

D O I：

10.1128/JVI.05137-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus found in association with human prostate cancer and chronic fatigue syndrome, although these associations are controversial. XMRV shows at most 94% identity to known mouse retroviruses. Here we used XMRV-specific PCR to search for a more closely related source of XMRV in mice. While we could not find a complete copy, we did find a 3,600-bp region of XMRV in an endogenous retrovirus present in NIH/3T3 cells. These results show that XMRV has clear ancestors in mice and highlight another possible source of contamination in PCR assays for XMRV.

引用

页码：9247 / 9248

页数：2

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