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Ohio State Univ, Dorothy M Davis Heart & Lung Res Inst, Div Pharmaceut & Pharmaceut Chem, Coll Pharm,Coll Med,Dept Physiol & Cell Biol, Columbus, OH 43210 USA Ohio State Univ, Dorothy M Davis Heart & Lung Res Inst, Div Pharmaceut & Pharmaceut Chem, Coll Pharm,Coll Med,Dept Physiol & Cell Biol, Columbus, OH 43210 USA